Endothelial Progenitor Cells in Health and Disease

This textbook provides an overview of endothelial progenitor cells (EPCs) in health and diseases, covering their biology, characterization, and therapeutic applications. It highlights the role of EPCs in vasculogenesis and angiogenesis and discusses their association with cardiovascular diseases. The book also discusses the diagnostic and prognostic potential of EPCs and the challenges and solutions in translating their research to the clinic. Additionally, it explores the use of EPC-derived extracellular vesicles for the treatment of cardiovascular diseases.

Format: Hardback
Length: 191 pages
Publication date: 08 July 2022
Publisher: Nova Science Publishers Inc

We are thrilled to present this comprehensive textbook to the scientific community, titled "Endothelial Progenitor Cells in Health and Diseases." This timely publication delves into the rapidly evolving field of vascular biology, focusing on a crucial topic that has significant implications for healthcare. Written primarily for a life science audience and clinicians, the book offers a comprehensive introduction to the fundamentals of endothelial progenitor cells (EPCs) biology, as well as the latest characterization and definition in health and diseases.

Section One: Endothelial Cell Progenitor Isolation Methods and Biological Characterization

In this section, the authors report on the isolation methods and biological characterization of endothelial cell progenitors. The discovery of EPCs has revolutionized our understanding of vasculogenesis, challenging the previous notion that vasculogenesis could only occur during embryogenesis. The authors highlight that both vasculogenesis and angiogenesis may play synergistic roles in postnatal revascularization. Furthermore, this chapter summarizes recent advancements in EPC biology, encompassing biological function, origin, definition, and classification. Clear definitions are provided for each EPC culture and isolation method to ensure clarity in this complex field.

Section Two: Biological Function Alteration of Endothelial Progenitor Cells in Cardiovascular Diseases

In Section Two, the authors delve into the biological function alteration of EPCs in cardiovascular diseases (CVD). Numerous large clinical trials have demonstrated a strong association between the number and biological function of EPCs and major adverse cardiovascular events. The diagnostic and prognostic potential of EPCs is of paramount importance in the context of CVD. The authors discuss the biological dysfunction mechanisms of EPCs and their scarcity in diabetic patients' peripheral blood. Preclinical studies have shown the feasibility, safety, and efficacy of EPC-based therapy in various disease states, leading to numerous clinical trials that have further confirmed the potential of this approach.

Section Three: Biological Dysfunction Mechanisms of Endothelial Progenitor Cells and Their Scarcity in Diabetic Patients

In Section Three, the authors provide a detailed description of the biological dysfunction mechanisms of EPCs and their scarcity in diabetic patients. Preclinical studies have shed light on the potential benefits of EPC-based therapy in diabetic patients. The authors discuss the mechanisms underlying EPC dysfunction in diabetes and the scarcity of EPCs in peripheral blood. They also explore the potential of EPC-based therapy in improving cardiovascular outcomes in diabetic patients.

Conclusion:

In conclusion, "Endothelial Progenitor Cells in Health and Diseases" is a valuable resource for scientists, clinicians, and researchers interested in the field of vascular biology. The book offers a comprehensive introduction to the fundamentals of EPCs biology, as well as the latest advancements in characterization and definition in health and diseases. The authors have successfully addressed the biological function alteration of EPCs in CVD, highlighting their diagnostic and prognostic potential. Additionally, the book provides valuable insights into the biological dysfunction mechanisms of EPCs and their scarcity in diabetic patients, paving the way for potential EPC-based therapies in this patient population. With its extensive coverage and expert insights, this textbook is a must-read for anyone seeking to advance their knowledge in the field of endothelial progenitor cells and their applications in healthcare.

ISBN-13: 9781685077945