Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications

The second edition of "Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications" is an authoritative and fully updated resource that provides a comprehensive understanding of applying kinetic principles to drug metabolizing enzymes and transporters. It is written in the highly successful Methods in Molecular Biology series format and includes chapters on enzyme kinetics, enzyme and transporter structures, modeling approaches, variability, and expanded case studies.

Format: Paperback / softback
Length: 881 pages
Publication date: 18 July 2022
Publisher: Springer-Verlag New York Inc.

This second edition delves deeper into the principles of applying kinetic principles to drug metabolizing enzymes and transporters. The book is organized into six comprehensive sections, each dedicated to exploring fundamental aspects of enzyme kinetics, enzyme and transporter structures, emphasizing specific oxidative and conjugative drug metabolizing enzymes and drug transporters, presenting modeling approaches for drug metabolizing enzymes and transporters, delving into the understanding of variability, both experimental and interindividual (pharmacogenomic), and offering expanded case studies that provide real-life examples of applying these principles. Written in the renowned Methods in Molecular Biology series format, the chapters feature introductions to their respective topics, accompanied by step-by-step instructions with readily reproducible laboratory protocols, and helpful tips on troubleshooting and avoiding common pitfalls, with extensive cross-referencing to aid in learning.

Authoritative and thoroughly revised, Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications, Second Edition serves as a valuable teaching resource for both novice and advanced scientists seeking to grasp the fundamental concepts of this field.

Weight: 1701g
Dimension: 254 x 178 (mm)
ISBN-13: 9781071615560
Edition number: 2nd ed. 2021