Epigenetics and DNA Damage

Epigenetics and DNA Damage explores the relationship between DNA damage, epigenetic modifications, and chromatin regulation, offering insights into disease development and potential epigenetic therapies.

Format: Paperback / softback
Length: 336 pages
Publication date: 26 August 2022
Publisher: Elsevier Science & Technology

Scientists have acknowledged the significance of epigenetic mechanisms in the response to DNA damage, yet the intricate, mechanistic connection between chromatin regulation and DNA repair remains largely unexplored. By gaining a deeper understanding of how these processes interrelate in time and space and contribute to developmental processes, we may uncover innovative avenues for research and the development of novel disease treatments.

Epigenetics and DNA Damage, a groundbreaking volume in the Translational Epigenetics series, provides a comprehensive exploration of the intricate relationship between DNA Damage, epigenetic modifications, and chromatin regulation. In the early chapters, the fundamental science of DNA damage is addressed, along with its association with diverse epigenetic mechanisms such as DNA methylation, post-translational histone modifications, histone variants, chromatin remodeling, microRNAs, and long non-coding RNAs. This foundation is then built upon to examine the interplay between DNA damage and epigenetics in areas such as metabolism, aging, cellular differentiation, immune function, stem cell biology, and cancer. The book seamlessly integrates recent research findings with their translational applications in disease understanding, highlighting the potential for epigenetic therapies that combine DNA damage induction and epigenetic alteration. Furthermore, informative chapters are included to guide researchers in analyzing DNA damage and epigenetic alterations in their studies.

By delving into the complexities of epigenetics and DNA damage, this book offers valuable insights into the field and serves as a crucial resource for researchers, clinicians, and students alike. It sheds light on the potential for epigenetic interventions to improve our understanding and treatment of diseases, paving the way for personalized medicine and targeted therapies in the future.

Weight: 692g
Dimension: 192 x 234 x 20 (mm)
ISBN-13: 9780323910811