Epigenetics in Human Disease

Epigenetics in Human Disease, Third Edition explores the role of epigenetics in various diseases, including cancer, autoimmune disorders, aging, metabolic disorders, neurological disorders, and cardiovascular disease. It covers topics such as molecular mechanisms, epigenetic technology, and clinical translation of research. The book is fully revised and up-to-date, discussing current interest in epigenetic disease research, including stem cell epigenetic therapy, bioinformatic analysis of NGS data, imprinting disorders, microRNA in cancer, epigenetic approaches to control obesity, and epigenetics in cardiovascular disease. It also includes online epigenetic tools and datasets, early-life programming of epigenetics, addiction and suicide, and epigenetic approaches to regulating and preventing diabetes, cardiac disease, allergic disorders, Alzheimer's disease, respiratory diseases, and other human maladies.

Format: Mixed media product
Length: 1300 pages
Publication date: 01 September 2023
Publisher: Elsevier Science Publishing Co Inc

Epigenetics in Human Disease, Third Edition delves into the intricate realm of diseases and conditions where epigenetic mechanisms have been extensively studied, encompassing a wide range of topics such as cancer, autoimmune disorders, aging, metabolic disorders, neurological disorders, and cardiovascular disease. This comprehensive textbook offers a comprehensive exploration of the science, from molecular mechanisms and epigenetic technology to the clinical translation of recent research. It caters to individuals with diverse interests, from those seeking a fundamental understanding of epigenetics to those interested in therapeutic interventions for epigenetic-based disorders. Throughout, a strong emphasis is placed on elucidating and applying key concepts in emerging research and clinical practice.

Fully revised and updated, this Third Edition covers the latest developments in epigenetic disease research, including stem cell epigenetic therapy, bioinformatic analysis of next-generation sequencing data, epigenetic mechanisms of imprinting disorders, the role of microRNAs in cancer, epigenetic approaches to control obesity, epigenetics and airway disease, and epigenetics in cardiovascular disease. Additional sections delve into online epigenetic tools and datasets, early-life programming of epigenetics in age-related diseases, the epigenetics of addiction and suicide, and epigenetic strategies for regulating and preventing diabetes, cardiac disease, allergic disorders, Alzheimer's disease, respiratory diseases, and numerous other human maladies.

To enhance understanding, each chapter now includes chapter summaries, definitions, vibrant imagery, and figures, as well as step-by-step methods and disease research case studies. This textbook serves as a valuable resource for researchers, clinicians, students, and anyone interested in gaining a deeper understanding of epigenetics and its implications in human health and disease.

Weight: 450g
Dimension: 234 x 191 (mm)
ISBN-13: 9780443218118
Edition number: 3 ed