Epigenetics of Stress and Stress Disorders

Epigenetics of Stress and Stress Disorders explores the epigenetic mechanisms involved in modifying DNA following prolonged stress or trauma, providing a foundation for understanding stress disorders and their genomics. It highlights recent research on epigenome-wide association studies, noncoding RNA, telomere shortening, and the long-term physical effects of PTSD. The book also examines the effect of adversity during sensitive periods or development and across the life span, and considers potential transgenerational stress-induced epigenetic alterations.

Format: Paperback / softback
Length: 420 pages
Publication date: 18 February 2022
Publisher: Elsevier Science Publishing Co Inc

The Epigenetics of Stress and Stress Disorders, a groundbreaking addition to the Translational Epigenetics series, delves into the intricate mechanisms underlying the modification of DNA caused by prolonged stress or trauma. This comprehensive volume explores the physiological and molecular effects of stress on the body, ultimately leading to the development of stress disorders.

The book begins by establishing a solid foundation for understanding stress disorders, encompassing psychiatric, biological, and phenomenological perspectives. It then delves into the genomics of stress disorders, providing a comprehensive overview of the genetic factors involved. Chapter authors present a range of recent epigenetic research, highlighting epigenome-wide association studies (EWAS), exciting advancements in noncoding RNA studies, potential implications of prolonged stress on telomere shortening, and the long-term physical consequences of PTSD on patients' health.

Furthermore, the book examines the impact of adversity during sensitive periods or development and across the lifespan. It concludes by exploring potential transgenerational stress-induced epigenetic alterations on future offspring and key areas of research for public health. Additionally, it discusses the potential for epigenetic therapeutics or "epidrugs" to address these disorders.

The Epigenetics of Stress and Stress Disorders is a vital resource for researchers, clinicians, and individuals seeking to gain a deeper understanding of the complex interplay between stress, genetics, and health. Its comprehensive coverage and insightful analysis provide valuable insights into the field, paving the way for future advancements in epigenetic research and therapeutic interventions.

Weight: 450g
Dimension: 235 x 191 (mm)
ISBN-13: 9780128230398