Eukaryome Impact on Human Intestine Homeostasis and Mucosal Immunology: Overview of the First Eukaryome Congress at Institut Pasteur. Paris, October 16-18, 2019.

The origin of emerging infections is complex, and poverty, urbanization, climate change, conflicts, and population migrations all play a role. The intestine is a major target of these infections, and the microbiome, a complex and dynamic population of 100 trillion microbes, is a focus of research. This book presents an overview of the science presented and discussed at the First Eukaryome Congress, held at the Pasteur Institute in Paris in 2019, covering topics such as the phylogenetic, prevalence, and diversity of intestinal eukaryotic microbes, their historical evolution, and their potential contributions to mucosal immune homeostasis. It also discusses integrative biology to study parasite-host interactions and the exploitation of tissue engineering and microfluidics to establish 3D systems that help to understand homeostasis and pathological processes in the human intestine.

Format: Paperback / softback
Length: 367 pages
Publication date: 02 June 2021
Publisher: Springer Nature Switzerland AG

Multiple demographic or economic factors contribute to the emergence of infectious diseases, including poverty, urbanization, climate change, conflicts, and population migrations. These factors pose significant challenges in assessing the impact of parasitic diseases on public health, particularly in the context of the intestine, which serves as a rich nutrient-enriched environment housing a complex and dynamic population of 100 trillion microbes, known as the microbiome. While most research on the microbiome primarily focuses on bacteria, it is important to recognize that the gut ecosystem is inhabited by a diverse array of uni- and multi-cellular eukaryotic organisms that may prey on these bacteria.

Our specific interest lies in the families of eukaryotic microbes inhabiting the intestine, referred to as the "intestinal eukaryome," which encompasses fungi, protists, and helminths. The understanding of the reciprocal influence between the microbiome and the eukaryome, as well as their combined impact on homeostasis and intestinal diseases, remains limited and is considered an emerging field of research. Furthermore, the factors that distinguish pathogenic eukaryotes from commensals remain largely unknown.

This book aims to provide an overview of the scientific presentations and discussions that took place during the First Eukaryome Congress, held from October 16th to 18th, 2019, at the Pasteur Institute in Paris. The book covers various topics, including:

Phylogenetic, prevalence, and diversity of intestinal eukaryotic microbes: Understanding the evolutionary history, distribution, and potential contributions of these microbes to mucosal immune homeostasis.

Integrative biology: Employing multidisciplinary approaches to study the molecular cell biology of parasite-host interactions and the various parameters underlying infectious processes.

Exploitation of tissue engineering and microfluidics: Developing three-dimensional (3D) systems to better understand host-parasite interactions and the dynamics of infectious diseases in the intestinal environment.

By exploring these topics, this book aims to advance our knowledge of the intestinal eukaryome and its role in shaping host health and disease. It provides valuable insights into the complex interplay between microbes, the immune system, and the gastrointestinal tract, with implications for developing new strategies for prevention, treatment, and management of parasitic diseases.

Weight: 593g
Dimension: 235 x 155 (mm)
ISBN-13: 9783030448288
Edition number: 1st ed. 2020