Experimental Models of Infection, Inflammation and Injury

Experimental Models of Infection, Inflammation and Injury, Volume 168 provides step-by-step protocols for utilizing experimental model systems, including murine T cell transfer colitis, acute graft-versus-host disease, multiple sclerosis, rheumatoid arthritis, pancreatic cancer, thermal injury, and intestinal permeability.

Format: Hardback
Length: 362 pages
Publication date: 01 April 2022
Publisher: Elsevier Science & Technology

Experimental Models of Infection, Inflammation, and Injury, Volume 168 is a comprehensive resource for scientific researchers seeking to effectively utilize experimental model systems in their research endeavors. This latest edition offers step-by-step protocols that enable researchers to explore various aspects of infection, inflammation, and injury.

The book is divided into several chapters, each focusing on a specific topic. Some of the notable chapters include:

Induction and Evaluation of Murine T Cell Transfer Colitis: This chapter provides detailed protocols for inducing and evaluating T cell transfer colitis, a model of inflammatory bowel disease. It discusses the use of different mouse strains, immunization strategies, and assessment methods to study the immune response and disease progression.

Modelling acute graft-versus-host disease (aGVHD) in murine bone marrow transplantation (BMT) models with MHC disparity: This chapter explores the use of mouse models to study aGVHD, a severe complication of BMT where donor T cells attack recipient cells. It discusses the development of models with MHC disparity to mimic the immune interactions involved in aGVHD.

Mouse models of Graft-Versus-Host Disease: This chapter provides an overview of different mouse models used to study graft-versus-host disease, including models of acute and chronic GVHD. It discusses the advantages and limitations of these models and the methods used to induce and assess disease manifestations.

Preclinical Model of Multiple Sclerosis: Methods in Autoimmune Demyelination: This chapter focuses on developing preclinical models of multiple sclerosis using autoimmune demyelination. It discusses the methods used to induce demyelination, evaluate disease progression, and study the immune response in these models.

Preclinical model of Multiple Sclerosis: focal, chemical, or demyelination: This chapter explores the use of different preclinical models of multiple sclerosis to study focal, chemical, or demyelination-related mechanisms. It discusses the development of models using specific toxins, immune cells, and genetic manipulation techniques.

Investigating demyelination, efficient remyelination, and remyelination failure in organotypic cerebellar slice cultures: workflow and practical tips: This chapter provides detailed protocols for investigating demyelination, efficient remyelination, and remyelination failure in organotypic cerebellar slice cultures. It discusses the use of slice cultures, imaging techniques, and assessment methods to study the neurobiology of demyelination and remyelination.

Other notable sections in the book cover Rheumatoid Arthritis: Methods for Two Murine Models, Induction of Pancreatitis in Mice with Susceptibility to Pancreatic Cancer, Small Animal Models of Thermal Injury, Large Animal Models of Thermal Injury, Small animal models of localized heart irradiation, Methods for Induction and Assessment of Intestinal Permeability in Rodent Models of Radiation Injury, and more.

Experimental Models of Infection, Inflammation, and Injury, Volume 168 is an invaluable resource for researchers in the fields of infectious diseases, immunology, and injury. With its comprehensive coverage and step-by-step protocols, it enables researchers to advance their understanding of these complex processes and develop new therapies and interventions. Whether you are a novice or an experienced researcher, this book will provide you with the tools and knowledge you need to succeed in your research endeavors.

Dimension: 229 x 152 (mm)
ISBN-13: 9780323899451