Fibroblast Growth Factor 23

Fibroblast Growth Factor 23 (FGF23) is a bone-derived factor that targets the kidney, regulating phosphate metabolism and other functions. This book covers exciting research on its effects, signaling receptors, and mediators, making it an ideal reference source on FGF23 for researchers and clinicians in biochemistry, pharmacology, and nephrology.

Format: Paperback / softback
Length: 376 pages
Publication date: 09 April 2021
Publisher: Elsevier Science Publishing Co Inc

Fibroblast Growth Factor 23 (FGF23) is a fascinating molecule that was initially identified as a bone-derived factor with a specific target in the kidney. This comprehensive book delves into exciting research that reveals the intricate mechanisms behind the diverse effects of FGF23 in different target tissues. It explores how FGF23 operates as a regulator of phosphate metabolism and goes beyond its traditional role. Furthermore, it sheds light on novel concepts of FGF receptor signaling, providing a deeper understanding of this complex signaling pathway.

The book is organized into several sections, each dedicated to exploring different aspects of FGF23. The first section provides an in-depth introduction to the biology and function of FGF23. It discusses the initial discovery of FGF23 as a bone-derived factor that targets the kidney and its role in regulating phosphate metabolism. The section also highlights the importance of FGF23 in bone health and other physiological processes.

The second section delves into the molecular mechanisms underlying FGF23 signaling. It explores the diverse signaling receptors and mediators involved in FGF23-mediated responses and their specific roles in different tissues. This section provides a comprehensive understanding of the complex interplay between FGF23 and its target cells, highlighting the importance of understanding these mechanisms for developing targeted therapies.

The third section focuses on the clinical implications of FGF23. It discusses the role of FGF23 in various diseases, including osteoporosis, kidney disease, and cancer. The section highlights the latest research findings and clinical trials that have shed light on the potential therapeutic applications of FGF23 in these conditions. It also provides insights into the challenges and limitations of using FGF23 as a therapeutic agent.

The fourth section covers biochemistry, pharmacology, and nephrology, providing a comprehensive understanding of the molecular mechanisms and clinical applications of FGF23. It discusses the synthesis, structure, and function of FGF23, as well as the mechanisms of its action and its interactions with other signaling pathways. The section also provides information on the pharmacokinetics and pharmacodynamics of FGF23 and its potential side effects.

In conclusion, Fibroblast Growth Factor 23: A Comprehensive Review is an essential reference source for researchers, clinicians, and students interested in understanding the biology, signaling mechanisms, and clinical applications of FGF23. With its extensive coverage of research, biochemistry, pharmacology, and nephrology, this book provides a comprehensive understanding of this fascinating molecule and its potential therapeutic implications. Whether you are a scientist, clinician, or student, this book will be a valuable resource for your research and learning.

Weight: 1022g
Dimension: 216 x 274 x 22 (mm)
ISBN-13: 9780128180365