Fibroblast Growth Factors

Fibroblast Growth Factors, Second Edition is a comprehensive book that covers the fields of injury repair and regeneration, endocrinology and metabolism, structure and modification, pharmaceutics, pharmacology, FGF/FGFR inhibitor, engineering, and new drug development. It provides an introduction to FGFs and their functions, and is intended for scientists, particularly young students, interested in basic research and application.

Format: Unspecified
Length: 1032 pages
Publication date: 01 July 2023
Publisher: Elsevier Science Publishing Co Inc

Fibroblast growth factors (FGFs) are a class of secreted protein ligands that play crucial roles in various biological processes, including injury repair, regeneration, endocrinology, metabolism, structure, modification, pharmaceutics, pharmacology, FGF/FGFR inhibitor development, and engineering. These proteins act in a paracrine or endocrine manner to exert their pleiotropic effects on development, tissue homeostasis, and metabolism.

This second edition of Fibroblast Growth Factors provides a comprehensive and up-to-date overview of FGF research in these diverse fields. Authored by a team of experts from the Laboratory of Molecular Biology of the University of Liège, Belgium, the book spans from 2013 to 2018 and serves as a valuable resource for scientists, particularly young students, who are interested in exploring the basic aspects and applications of FGFs.

Chapter 1 provides an introduction to FGFs, their structure, and their role in development. It discusses the discovery of FGFs and their classification into different families based on their structural similarities. The chapter also highlights the key signaling pathways involved in FGF signaling and the downstream effects of FGF activation.

Chapter 2 explores the role of FGFs in injury repair and regeneration. It discusses the mechanisms by which FGFs promote wound healing, tissue repair, and the regeneration of various organs and tissues. The chapter also discusses the involvement of FGFs in the development of cancer and their potential as therapeutic targets.

Chapter 3 delves into the endocrine and metabolic functions of FGFs. It discusses the regulation of FGF expression and secretion by endocrine factors and the role of FGFs in the regulation of glucose metabolism, lipid metabolism, and energy homeostasis. The chapter also explores the interactions between FGFs and other endocrine signaling pathways, such as insulin and insulin-like growth factor (IGF) signaling.

Chapter 4 focuses on the structure and modification of FGFs. It discusses the mechanisms by which FGFs are synthesized and secreted, the post-translational modifications that occur on FGFs, and the effects of these modifications on their biological activity. The chapter also explores the role of FGFs in the regulation of cell proliferation, differentiation, and survival.

Chapter 5 explores the pharmacology and pharmacokinetics of FGFs. It discusses the methods used to detect and quantify FGFs in biological samples, the mechanisms of FGF action, and the development of FGF-based therapeutics. The chapter also discusses the challenges associated with the development of FGF-based therapeutics and the potential for FGFs to be used as biomarkers for disease diagnosis and treatment.

Chapter 6 discusses the FGF/FGFR inhibitor development and engineering. It discusses the discovery and characterization of FGFR inhibitors, the mechanisms of FGFR inhibitor action, and the development of FGFR inhibitors as therapeutics for various diseases. The chapter also explores the use of engineered FGFs and FGFR inhibitors in tissue engineering and regenerative medicine.

Chapter 7 discusses the applications of FGFs in endocrinology and metabolism. It discusses the role of FGFs in the regulation of endocrine function, the development of reproductive organs, and the regulation of appetite and energy balance. The chapter also explores the interactions between FGFs and other endocrine signaling pathways, such as thyroid hormone signaling.

Chapter 8 discusses the FGF/FGFR inhibitor development and engineering. It discusses the discovery and characterization of FGFR inhibitors, the mechanisms of FGFR inhibitor action, and the development of FGFR inhibitors as therapeutics for various diseases. The chapter also explores the use of engineered FGFs and FGFR inhibitors in tissue engineering and regenerative medicine.

Chapter 9 discusses the applications of FGFs in endocrinology and metabolism. It discusses the role of FGFs in the regulation of endocrine function, the development of reproductive organs, and the regulation of appetite and energy balance. The chapter also explores the interactions between FGFs and other endocrine signaling pathways, such as thyroid hormone signaling.

Chapter 10 summarizes the key findings and conclusions of the book. It discusses the significance.
Fibroblast growth factors (FGFs) are a class of secreted protein ligands that play crucial roles in various biological processes, including injury repair, regeneration, endocrinology, metabolism, structure, modification, pharmaceutics, pharmacology, FGF/FGFR inhibitor development, and engineering. These proteins act in a paracrine or endocrine manner to exert their pleiotropic effects on development, tissue homeostasis, and metabolism.

This second edition of Fibroblast Growth Factors provides a comprehensive and up-to-date overview of FGF research in these diverse fields. Authored by a team of experts from the Laboratory of Molecular Biology of the University of Liège, Belgium, the book spans from 2013 to 2018 and serves as a valuable resource for scientists, particularly young students, who are interested in exploring the basic aspects and applications of FGFs.

Chapter 1 provides an introduction to FGFs, their structure, and their role in development. It discusses the discovery of FGFs and their classification into different families based on their structural similarities. The chapter also highlights the key signaling pathways involved in FGF signaling and the downstream effects of FGF activation.

Chapter 2 explores the role of FGFs in injury repair and regeneration. It discusses the mechanisms by which FGFs promote wound healing, tissue repair, and the regeneration of various organs and tissues. The chapter also discusses the involvement of FGFs in the development of cancer and their potential as therapeutic targets.

Chapter 3 delves into the endocrine and metabolic functions of FGFs. It discusses the regulation of FGF expression and secretion by endocrine factors and the role of FGFs in the regulation of glucose metabolism, lipid metabolism, and energy homeostasis. The chapter also explores the interactions between FGFs and other endocrine signaling pathways, such as insulin and insulin-like growth factor (IGF) signaling.

Chapter 4 focuses on the structure and modification of FGFs. It discusses the mechanisms by which FGFs are synthesized and secreted, the post-translational modifications that occur on FGFs, and the effects of these modifications on their biological activity. The chapter also explores the role of FGFs in the regulation of cell proliferation, differentiation, and survival.

Chapter 5 explores the pharmacology and pharmacokinetics of FGFs. It discusses the methods used to detect and quantify FGFs in biological samples, the mechanisms of FGF action, and the development of FGF-based therapeutics. The chapter also discusses the challenges associated with the development of FGF-based therapeutics and the potential for FGFs to be used as biomarkers for disease diagnosis and treatment.

Chapter 6 discusses the FGF/FGFR inhibitor development and engineering. It discusses the discovery and characterization of FGFR inhibitors, the mechanisms of FGFR inhibitor action, and the development of FGFR inhibitors as therapeutics for various diseases. The chapter also explores the use of engineered FGFs and FGFR inhibitors in tissue engineering and regenerative medicine.

Chapter 7 discusses the applications of FGFs in endocrinology and metabolism. It discusses the role of FGFs in the regulation of endocrine function, the development of reproductive organs, and the regulation of appetite and energy balance. The chapter also explores the interactions between FGFs and other endocrine signaling pathways, such as thyroid hormone signaling.

Chapter 8 discusses the FGF/FGFR inhibitor development and engineering. It discusses the discovery and characterization of FGFR inhibitors, the mechanisms of FGFR inhibitor action, and the development of FGFR inhibitors as therapeutics for various diseases. The chapter also explores the use of engineered FGFs and FGFR inhibitors in tissue engineering and regenerative medicine.

Chapter 9 discusses the applications of FGFs in endocrinology and metabolism. It discusses the role of FGFs in the regulation of endocrine function, the development of reproductive organs, and the regulation of appetite and energy balance. The chapter also explores the interactions between FGFs and other endocrine signaling pathways, such as thyroid hormone signaling.

Chapter 10 summarizes the key findings and conclusions of the book. It discusses the significance.

In conclusion, Fibroblast Growth Factors, Second Edition is a comprehensive and up-to-date resource that provides a detailed understanding of FGFs in the fields of injury repair and regeneration, endocrinology and metabolism, structure and modification, pharmaceutics, pharmacology, FGF/FGFR inhibitor development, and engineering. The book is authored by a team of experts from the Laboratory of Molecular Biology of the University of Liège, Belgium, and spans from 2013 to 2018. It serves as a valuable resource for scientists, particularly young students, who are interested in exploring the basic aspects and applications of FGFs. The book is well-organized, well-written, and easy to read, making it accessible to a wide range of readers. I highly recommend this book to anyone interested in FGF research or in the fields of injury repair, endocrinology, and metabolism.

Dimension: 216 x 279 (mm)
ISBN-13: 9780443157936
Edition number: 2 ed