From Malignant Transformation to Metastasis: Ion Transport in Tumor Biology

This book provides readers with comprehensive knowledge of the pathophysiology of cancer, focusing on the role of ion transport proteins, channels, and transporters in the development and progression of the disease. It highlights that dysregulated expression and/or function of ion transporters have been correlated with malignancy in the vast majority of tumor diseases. The authors describe how interactions between the tumor cells transportome and the environment reinforce mesenchymal behavior and contribute to cancer cell proliferation, migration, invasion, and metastasis.

Format: Paperback / softback
Length: 175 pages
Publication date: 25 April 2023
Publisher: Springer Nature Switzerland AG

This second book of the three-volume collection Ion Transport in Tumor Biology is a comprehensive resource for understanding the pathophysiology of cancer. The authors emphasize that ion transport proteins, channels, and transporters, collectively known as the transportome, play a crucial role in the development and progression of cancer. Epithelial cells, which make up nearly 90% of malignant tumor diseases, rely heavily on the transportome for their function. This volume focuses on molecular principles by demonstrating that dysregulated expression and/or function of ion transporters are associated with malignancy in the vast majority of tumor diseases.

Within the narrative of the various chapters, the authors outline various malfunctions of the transportome and their locations at different stages of the metastatic cascade. They describe how interactions between the tumor cells transportome and the environment reinforce mesenchymal behavior of cancer cells, contributing to their uncontrolled proliferation, migration, invasion, intra- and extravasation, and ultimately the formation of metastases.

As part of a three-volume collection, this book will captivate members of the active research community, as well as clinicians specializing in cancer care. It provides a deep understanding of the molecular mechanisms underlying cancer progression and offers valuable insights into potential therapeutic targets and strategies for cancer treatment.

Weight: 302g
Dimension: 235 x 155 (mm)
ISBN-13: 9783030998028
Edition number: 1st ed. 2022