From Proteins to Proteomics: Basic Concepts, Techniques, and Applications

Proteomics is the study of all proteins in human and other living systems, using high-throughput technologies and platforms for biomedical and pharmaceutical applications. This book covers protein basics, techniques, mass spectrometry, quantitative proteomics, interactomics, and advancements in sample preparation, workflow, chromatography, and quantitative proteomics. It highlights the value of high-throughput proteomics technologies for studying disease pathobiology, identifying biomarkers, and developing drug/vaccine targets.

Format: Hardback
Length: 262 pages
Publication date: 29 December 2022
Publisher: Taylor & Francis Ltd

Proteomics is a comprehensive field of study that aims to unravel the intricate workings of proteins in human and other living systems. By examining the properties and characteristics of these essential macromolecules, researchers seek to gain a comprehensive understanding of cellular processes. This field employs rapidly evolving high-throughput technologies and innovative platforms to facilitate the analysis of large protein datasets.

The study of proteomics involves the application of various techniques, including gel-based proteomics, mass spectrometry, and quantitative proteomics. These methods enable researchers to identify, characterize, and quantify proteins, providing valuable insights into their functions, interactions, and dynamics within cells.

One of the key applications of proteomics is in biomedical research. By analyzing protein expression patterns and protein-protein interactions, researchers can gain insights into disease development, drug response, and personalized medicine. Proteomics has played a pivotal role in identifying new biomarkers for various diseases, such as cancer, Alzheimer's, and cardiovascular diseases.

In addition to biomedical applications, proteomics has significant implications in the pharmaceutical industry. By identifying potential drug targets and developing novel therapeutics, proteomics can help accelerate drug discovery and development processes.

This book aims to provide a comprehensive understanding of the basics of proteins and proteomics, as well as advanced techniques and applications. It covers topics such as gel-based proteomics, mass spectrometry, quantitative proteomics, interactomics, sample preparation, mass spectrometry workflow, chromatography technologies, and quantitative proteomics.

The book emphasizes the application and challenges of various high-throughput integrated proteomics technologies, including next-generation sequencing, mass spectrometry-based proteomics, and bioinformatics analysis. These technologies enable fast and accurate screening of thousands of biomolecules, providing valuable insights into disease pathobiology and the identification of next-generation biomarkers and potential drug/vaccine targets.

However, the field of proteomics also faces several challenges, such as data interpretation, reproducibility, and scalability. Addressing these challenges requires the development of new analytical methods, computational tools, and standardized protocols.

In conclusion, proteomics is a rapidly evolving field that holds immense potential for advancing our understanding of biological processes and developing innovative solutions for healthcare and pharmaceutical industries. By leveraging the power of high-throughput technologies and advanced analytical techniques, researchers can unravel the complex molecular mechanisms underlying diseases and discover new therapies to improve human health.

Weight: 660g
Dimension: 254 x 178 (mm)
ISBN-13: 9780367566173