G Protein-Coupled Receptors: Immobilization and Applications in Drug Discovery

This book explores the progress made in functional immobilization of G protein-coupled receptors through site-specific or orientated recognition in non-covalent and covalent manners. It discusses the applications of protein immobilization in drug discovery and protein-ligand interaction analysis, with an emphasis on G protein-coupled receptors. The merits, opportunities, and disadvantages of different immobilization methods are analyzed, and a perspective for future directions is presented. The book appeals to a broad readership, particularly researchers in analytical chemistry, bioconjugate chemistry, and chemical biology.

Format: Paperback / softback
Length: 91 pages
Publication date: 21 February 2023
Publisher: Springer Verlag, Singapore

The last decade has witnessed a remarkable resurgence in the field of G protein-coupled receptor (GPCR) research, heralding the dawn of the "post-structural biology" era. As an emerging approach for state-of-the-art immobilization, this book delves into the exploration of the inherent elegance of naturally occurring biochemical reactions by harnessing their high specificity and robust reactivity within complex systems, such as site-specific conjugation through covalent recognition between enzymes and their substrates. With a focus on protein-drug interactions, this book also provides a comprehensive review of the applications of protein immobilization, particularly in the context of GPCRs, in drug discovery and protein-ligand interaction analysis. Furthermore, it critically analyzes the merits, opportunities, and limitations of various immobilization methods, offering a forward-looking perspective for future directions in this field. Given its broad scope, this book appeals to a diverse readership, including researchers engaged in analytical chemistry, bioconjugate chemistry, chemical biology, and related disciplines, as well as educators teaching relevant majors in colleges and universities.

The field of G protein-coupled receptor (GPCR) research has experienced a remarkable resurgence in the past decade, marking the dawn of the "post-structural biology" era. As an emerging approach for state-of-the-art immobilization, this book delves into the exploration of the inherent elegance of naturally occurring biochemical reactions by harnessing their high specificity and robust reactivity within complex systems, such as site-specific conjugation through covalent recognition between enzymes and their substrates. With a focus on protein-drug interactions, this book also provides a comprehensive review of the applications of protein immobilization, particularly in the context of GPCRs, in drug discovery and protein-ligand interaction analysis. Furthermore, it critically analyzes the merits, opportunities, and limitations of various immobilization methods, offering a forward-looking perspective for future directions in this field. Given its broad scope, this book appeals to a diverse readership, including researchers engaged in analytical chemistry, bioconjugate chemistry, chemical biology, and related disciplines, as well as educators teaching relevant majors in colleges and universities.

Weight: 174g
Dimension: 235 x 155 (mm)
ISBN-13: 9789819900770
Edition number: 1st ed. 2023