Gene Regulation and Therapeutics for Cancer

This book discusses gene regulation and targeted therapies in cancer, focusing on transcriptional dysregulation and oncogenic drivers. It highlights the development of targeted therapeutics against specific oncogenic drivers, such as kinases, in intracellular signaling cascades.

Format: Paperback / softback
Length: 322 pages
Publication date: 15 September 2022
Publisher: Taylor & Francis Ltd

Differential gene regulation and targeted therapy play pivotal roles in the treatment of various cancers. This comprehensive book delves into the intricate mechanisms of gene regulation and targeted therapies in different malignancies. It provides a thorough examination of the transcriptional dysregulation that characterizes cancer, exploring the role of specific transcriptional regulators as definitive oncogenic drivers in solid tumors. The book then discusses the transcriptional effectors of these programs and their specific targets.

To date, the majority of targeted therapeutics developed have been focused on a limited set of oncogenic drivers, such as kinases that function within intracellular signaling cascades found on the cell surface or in the cytoplasm. These targeted therapies aim to disrupt the functioning of these drivers, thereby inhibiting cancer cell growth and progression.

The field of gene regulation and targeted therapy is constantly evolving, with ongoing research and clinical trials aimed at discovering new therapeutic targets and developing more effective treatment strategies. By understanding the complexities of transcriptional regulation and targeted therapy, researchers and healthcare professionals can work towards improving the outcomes of cancer patients and developing personalized treatment plans that target the specific genetic abnormalities driving each patient's disease.

Weight: 603g
Dimension: 234 x 156 (mm)
ISBN-13: 9780367541163