Genomic Structural Variants in Nervous System Disorders

This volume covers the detection of structural variants (SVs), which require different strategies than the ones used for single nucleotide variants (SNVs). It provides a combination of latest "wet lab" methods and computational pipelines for all SV classes, including transposable elements, long read sequencing, genomic mosaicism, and optical genome mapping. The chapters include detailed advice from specialists to help readers get successful results in their laboratory.

Format: Hardback
Length: 272 pages
Publication date: 01 June 2022
Publisher: Springer-Verlag New York Inc.

This comprehensive volume delves into the intricate realm of structural variants (SVs), presenting a distinct approach compared to single nucleotide variants (SNVs). Its primary objective is to equip readers with a fusion of cutting-edge "wet lab" methods and computational pipelines tailored to detect and analyze all classes of SVs. Spanning a wide range of topics, the chapters in this book explore essential aspects such as the identification of transposable elements (TEs) from short read data, the utilization of long read sequencing for comprehensive analysis of multiple variable number tandem repeat (MVNTRA) sequences, the study of genomic mosaicism in the nervous system, and the application of optical genome mapping techniques. In keeping with the Neuromethods series' hallmark style, each chapter offers a wealth of detailed information and invaluable guidance from esteemed specialists, ensuring that readers can achieve successful outcomes in their laboratory endeavors.

Genomic Structural Variants in Nervous System Disorders stands as a pivotal resource for scientists and researchers seeking to delve deeper into this critical field. By presenting a holistic perspective and offering a fusion of cutting-edge methodologies, this book empowers readers to unravel the complexities of SVs and their impact on human health. Whether you are a seasoned researcher or a newcomer to the field, this comprehensive volume will serve as a valuable guide, facilitating your understanding of structural variations and their significance in neurological disorders.

Weight: 743g
Dimension: 254 x 178 (mm)
ISBN-13: 9781071623565
Edition number: 1st ed. 2022