Gigantism and Acromegaly

Gigantism and Acromegaly is a comprehensive book that covers pituitary experts, genetic analysis, clinical analysis, and new therapeutic approaches to growth hormone over-secretion. It is a valuable resource for endocrinologists, pediatricians, internists, neurosurgeons, geneticists, pharmaceutical companies, students, residents, and fellows in medicine and endocrinology and genetics.

Format: Paperback / softback
Length: 310 pages
Publication date: 09 June 2021
Publisher: Elsevier Science Publishing Co Inc

Gigantism and Acromegaly is a comprehensive resource that brings together experts in pituitary disorders, spanning from bench research to genetic analysis, clinical evaluation, and innovative therapeutic approaches. Serving as a valuable reference for endocrinologists, pediatricians, internists, neurosurgeons, and geneticists, this book provides comprehensive coverage of growth hormone over-secretion and its diagnosis and treatment. Pharmaceutical companies can also utilize it as a valuable resource for drug development and research. Additionally, students, residents, and fellows in medicine, endocrinology, and genetics will find this book invaluable, as it offers a single, up-to-date review of the molecular biology of gigantism and acromegaly, along with recommended evaluation and management strategies.

Acromegaly, a rare pituitary disorder, exerts a gradual transformation on its adult victims, gradually altering their physical features. This includes larger hands, feet, a bigger jaw, forehead, nose, and lips. The underlying cause of acromegaly is typically a benign pituitary tumor, and the symptoms exhibited by patients can vary significantly, making a precise diagnosis challenging and prolonging their suffering for years. Early detection is paramount in the management of acromegaly, as the progressive pathologic effects of increased growth hormone (GH) production can lead to life-threatening complications. These complications encompass cardiovascular, cerebrovascular, and respiratory disorders, as well as the development of malignancies.

Understanding the molecular biology of gigantism and acromegaly is crucial in developing effective treatment strategies. This book delves into the underlying mechanisms of GH over-secretion, exploring the role of growth hormone receptors, signaling pathways, and the impact of GH on various physiological systems. It also discusses the diagnostic tools and techniques used to identify acromegaly, including imaging studies, blood tests, and pituitary gland biopsies.

Therapeutic interventions for acromegaly have evolved significantly over the years. This book provides an overview of current treatment options, including medication, surgery, and radiotherapy. It discusses the advantages and disadvantages of each approach, as well as the potential risks and benefits associated with each treatment modality. Additionally, the book explores emerging therapeutic strategies, such as gene therapy and targeted therapies, which hold promise for improving the management and outcomes of acromegaly.

Gigantism and Acromegaly serves as a valuable resource for healthcare professionals, researchers, and students alike. It provides a comprehensive and up-to-date understanding of pituitary disorders, enabling practitioners to effectively diagnose, treat, and manage patients with acromegaly. By integrating cutting-edge research with clinical expertise, this book contributes to the advancement of pituitary medicine and ultimately improves the quality of life for individuals affected by these conditions.

Weight: 656g
Dimension: 191 x 231 x 25 (mm)
ISBN-13: 9780128145371