Handbook of Drug Metabolism, Third Edition

This book is the ultimate resource on drug metabolism, covering recent scientific and regulatory advancements, with new chapters on large molecules disposition, stereo-selectivity, and drug transporters.

Format: Paperback / softback
Length: 736 pages
Publication date: 31 March 2021
Publisher: Taylor & Francis Ltd

This comprehensive book remains the gold standard in the field of drug metabolism, with a strong emphasis on the latest scientific and regulatory advancements. It has undergone a thorough update to reflect the most recent developments that have taken place over the past five years. In addition to covering traditional topics such as drug metabolism pathways and enzymes, the book also includes dedicated chapters on emerging areas such as large molecules disposition, stereo-selectivity in drug metabolism, drug transporters, and metabolic activation of drugs.

To ensure the utmost accuracy and relevance, the authors of this book have drawn upon the expertise of new authors who have emerged as subject area experts in the decade since the first edition was published. These experts have contributed their valuable insights and contributions to make this edition an invaluable resource for researchers, academics, and practitioners alike.

One of the key features of this book is its comprehensive coverage of the drug transporter field. Drug transporters play a crucial role in the disposition of drugs, and their understanding is essential for predicting drug interactions, designing effective drug therapies, and addressing drug-related toxicities. The book provides detailed explanations of the different drug transporter classes, their mechanisms of action, and their role in drug metabolism.

Another notable aspect of this book is its emphasis on the disposition of protein therapeutics. Protein-based drugs, such as antibodies and enzymes, have become increasingly important in the treatment of various diseases. The book provides detailed insights into the mechanisms of protein disposition, including the role of liver and kidney enzymes, as well as the impact of genetic variations on drug metabolism.

Furthermore, the book includes chapters on metabolic activation of drugs, which is a critical step in the development of drug-related toxicities and drug-resistant bacteria. The authors discuss the mechanisms of drug activation, the role of cytochrome P450 enzymes, and the strategies used to mitigate the risk of drug-induced toxicities.

In conclusion, this book is an essential resource for anyone interested in drug metabolism. It provides a comprehensive and up-to-date overview of the field, covering both traditional and emerging topics. With the contributions of world-class experts and editors who are recognized leaders and deep content experts in the field, this book is sure to be a valuable asset to researchers, academics, and practitioners alike.

Weight: 1397g
Dimension: 254 x 178 (mm)
ISBN-13: 9780367779764
Edition number: 3 New edition