Handbook of Epigenetics: The New Molecular and Medical Genetics

The Handbook of Epigenetics: The New Molecular and Medical Genetics, Third Edition is a comprehensive guide to epigenetics, covering basic biology to clinical applications. It has been updated to include new chapters on single-cell epigenetics, DNA methylation clocks, transposable elements, X chromosome inactivation, and drug addiction. It emphasizes epigenomic analyses and incorporates multi-omics approaches, with step-by-step instructions and disease case studies. Live links to external datasets and resources aid in research and clinical translation.

Format: Hardback
Length: 918 pages
Publication date: 12 September 2022
Publisher: Elsevier Science & Technology

The Handbook of Epigenetics: The New Molecular and Medical Genetics, Third Edition is a comprehensive and up-to-date resource that delves into the realm of epigenetics, encompassing its fundamental principles, biological mechanisms, and clinical applications. This revised edition has been meticulously crafted to address the latest developments and emerging topics in epigenetics, ensuring that readers are well-informed about the field's latest advancements.

The Handbook is organized into nine chapters, each dedicated to exploring different aspects of epigenetics. The first chapter provides an introduction to epigenetics, defining its scope and explaining the key concepts and principles that underpin its study. Subsequent chapters delve into the biological mechanisms of epigenetic regulation, including DNA methylation, histone modifications, non-coding RNA, and chromatin structure.

The third chapter focuses on epigenetic mechanisms in development and disease, discussing how epigenetic alterations contribute to the development of various disorders such as cancer, neurological diseases, and cardiovascular diseases. The fourth chapter explores the clinical applications of epigenetics, discussing how epigenetic profiling can be used to diagnose and predict disease risk, develop personalized treatment strategies, and monitor disease progression.

The fifth chapter explores the epigenetics of aging, discussing how epigenetic changes contribute to the aging process and the development of age-related diseases. The sixth chapter examines the epigenetics of drug addiction, exploring how environmental factors and drug exposure can alter epigenetic patterns and contribute to addiction development.

The seventh chapter focuses on single-cell epigenetics, discussing how epigenetic regulation occurs at the cellular level and how it can be used to study cell differentiation, development, and disease. The eighth chapter explores the epigenetics of transposable elements, discussing how these mobile genetic elements contribute to epigenetic regulation and how they can be used to study gene expression and disease.

The ninth chapter discusses the epigenetics of the X chromosome, exploring how X chromosome inactivation and epigenetic regulation contribute to sex determination and the development of sex-related diseases.

Throughout the Handbook, greater emphasis is placed on epigenomic analyses and incorporating multi-omics approaches rather than gene-specific analyses. This approach allows for a more comprehensive understanding of epigenetic regulation and its role in disease development.

In addition to its comprehensive coverage of epigenetics, the Third Edition has been enhanced with step-by-step instructions in research methods, as well as easy-to-digest disease case studies and clinical trials that provide context and applied examples of recent advances in disease understanding and epigenetic therapeutics. These features empower researchers to reproduce the approaches and studies discussed and aid clinical translation.

Live links across chapters tie in relevant external datasets and resources, allowing readers to further explore the topics discussed and gain a deeper understanding of the field.

In conclusion, The Handbook of Epigenetics: The New Molecular and Medical Genetics, Third Edition is a valuable resource for researchers, clinicians, and students interested in epigenetics. With its comprehensive coverage, up-to-date information, and practical applications, this edition provides a solid foundation for understanding epigenetic mechanisms and their role in disease development. Whether you are a novice or an experienced epigeneticist, this Handbook will be an indispensable tool in your research and clinical practice.

Weight: 2384g
Dimension: 218 x 281 x 51 (mm)
ISBN-13: 9780323919098
Edition number: 3 ed