Heart Development and Disease

The book "Heart Development and Disease" covers new advances in the field, including Macrophages during heart valve development, Computational models of cardiovascular biology, Mechanisms of early sarcomere assembly, Role of RNA binding proteins during heart development and disease, Early heart development and morphogenesis, PSC models for development and disease, ECM or SHF development, Role of metabolism during heart development, Cellular ploidy in cardiac biology, and Genetics of CHD in the human population.

Format: Hardback
Length: 362 pages
Publication date: 01 March 2024
Publisher: Elsevier Science Publishing Co Inc

The 156th volume in the Current Topics in Developmental Biology series, Heart Development and Disease, showcases cutting-edge advancements in the field. This latest edition presents captivating chapters such as Macrophages during heart valve development, Computational models of cardiovascular biology, Mechanisms of early sarcomere assembly, Role of RNA binding proteins during heart development and disease, Early heart development and morphogenesis,PSC models for development and disease, ECM or SHF development, Role of metabolism during heart development, Cellular ploidy in cardiac biology, and Genetics of CHD in the human population.

Macrophages play a crucial role in the development of heart valves, contributing to their formation and function. Researchers have gained insights into the mechanisms by which macrophages interact with valve cells and influence valve development. Computational models have been developed to simulate cardiovascular biology, providing valuable tools for understanding the complex processes involved in heart function and disease. These models can help researchers analyze the effects of different factors on heart structure and function and identify potential therapeutic targets.

Early sarcomere assembly is a critical step in the development of heart muscle. Researchers have identified key proteins and signaling pathways that regulate this process, and have developed experimental techniques to study it in detail. Understanding the mechanisms of early sarcomere assembly is important for developing new treatments for heart diseases such as cardiomyopathy.

RNA binding proteins play a significant role in heart development and disease. These proteins bind to specific RNA sequences and regulate gene expression, influencing the development and function of heart cells. Researchers have identified several RNA binding proteins that are involved in heart development and disease, and have developed experimental techniques to study their function in vivo.

Early heart development and morphogenesis are critical stages in the development of the heart. Researchers have gained insights into the mechanisms by which heart cells migrate and differentiate, and have developed experimental techniques to study these processes in vitro. Understanding these processes is important for developing new treatments for heart diseases such as congenital heart defects.

PSC models for development and disease have gained popularity in recent years as a tool for studying heart development and disease. These models are derived from pluripotent stem cells and can be used to study the effects of different factors on heart development and function. PSC models have been used to study the role of genetics in heart disease, and have helped researchers identify new genetic mutations that are associated with heart disease.

ECM or SHF development is a critical component of heart development and function. Researchers have gained insights into the mechanisms by which ECM or SHF is formed and regulated, and have developed experimental techniques to study it in detail. Understanding the mechanisms of ECM or SHF development is important for developing new treatments for heart diseases such as atherosclerosis.

Role of metabolism during heart development is an emerging area of research. Researchers have identified several metabolic pathways that are important for heart development and function, and have developed experimental techniques to study them in vivo. Understanding the role of metabolism during heart development is important for developing new treatments for heart diseases such as diabetes and obesity.

Cellular ploidy in cardiac biology is a complex topic that involves the number of chromosomes in heart cells. Researchers have gained insights into the mechanisms by which cellular ploidy is regulated and how it affects heart function. Understanding cellular ploidy is important for developing new treatments for heart diseases such as arrhythmias and heart failure.

Genetics of CHD in the human population is a significant area of research. Researchers have identified several genetic mutations that are associated with heart disease, and have developed experimental techniques to study these mutations in vivo. Understanding the genetics of CHD is important for developing new treatments and prevention strategies for heart disease.

In conclusion, Heart Development and Disease, Volume 156 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters including Macrophages during heart valve development, Computational models of cardiovascular biology, Mechanisms of early sarcomere assembly, Role of RNA binding proteins during heart development and disease, Early heart development and morphogenesis,PSC models for development and disease, ECM or SHF development, Role of metabolism during heart development, Cellular ploidy in cardiac biology, and Genetics of CHD in the human population. These chapters provide valuable insights into the mechanisms of heart development and disease, and have the potential to lead to new treatments and prevention strategies for heart disease.

Dimension: 229 x 151 (mm)
ISBN-13: 9780128232972