Heat Shock Proteins of Malaria

This new edition provides an overview of heat shock proteins' role in the life cycle of malaria parasites, focusing on their structural and functional features as molecular chaperones. It discusses the latest prospects of targeting heat shock proteins in antimalarial drug discovery and highlights the role of these proteins in the development and function of subcellular and extracellular organelles associated with Plasmodium species. The book is a valuable resource for experts in heat shock protein research, parasitology, infectious diseases, cell stress, molecular biology, and drug discovery.

Format: Hardback
Length: 251 pages
Publication date: 27 September 2021
Publisher: Springer Nature Switzerland AG

This new edition delves into the intricate role of heat shock proteins in the life cycle of malaria parasites, particularly during their intracellular stages. Thoroughly revised and updated, this comprehensive work offers a comprehensive introduction to the structural and functional characteristics of heat shock proteins, with a special emphasis on their vital role as molecular chaperones in ensuring protein quality control. The focus is on the heat shock protein families from Plasmodium falciparum, exploring their significance in proteostasis and the development of malaria pathology. Moreover, the authors explore the latest prospects of targeting heat shock proteins in antimalarial drug discovery, either as standalone therapies or in combination approaches.

The book provides a detailed functional analysis of individual heat shock protein families and their cooperative interactions within functional networks, encompassing both the parasite-resident proteome and the exportome released into host cells during intracellular stages. Subcellular and extracellular organelles such as the apicoplast and the Maurers Clefts associated with Plasmodium species are discussed in depth, highlighting the role of heat shock proteins in their development and function.

With its multidisciplinary approach and incorporation of novel therapeutic solutions, this collection serves as a unique reference for experts in heat shock protein research, parasitology, infectious diseases, cell stress, molecular biology, and drug discovery. Furthermore, advancements in malaria control will play a crucial role in ending epidemics and ensuring healthy lives in alignment with the United Nations Sustainable Development Goals.

Weight: 571g
Dimension: 235 x 155 (mm)
ISBN-13: 9783030783969
Edition number: 2nd ed. 2021