Hepatic Fibrosis: Mechanisms and Targets

Hepatic Fibrosis: Mechanisms and Targets is a comprehensive book on liver extracellular matrix biology, covering molecular signaling pathways, cells, and factors that modulate fibrogenesis and fibrosis. It emphasizes the potential molecular targets to fight fibrosis and describes the cellular and molecular events that lead to cirrhosis, hepatocellular carcinoma, and death.

Format: Paperback / softback
Length: 274 pages
Publication date: 01 June 2022
Publisher: Elsevier Science & Technology

Hepatic Fibrosis: Mechanisms and Targets is a comprehensive and in-depth exploration of liver extracellular matrix biology, encompassing a wide range of topics related to fibrogenesis and fibrosis. This extensive volume delves into molecular signaling pathways, cells, and factors that play crucial roles in the development and progression of hepatic fibrotic tissue. By adopting an integrated approach, the book focuses on the intricate molecular and cellular mechanisms involved in the synthesis and degradation of hepatic fibrotic tissue, with a particular emphasis on identifying potential molecular targets for combating fibrosis.

This essential reference provides a detailed and pedagogical account of the cellular and molecular events that contribute to the progression of fibrosis, leading to cirrhosis, hepatocellular carcinoma, and ultimately death. By elucidating these mechanisms, readers gain a deeper understanding of the molecular underpinnings of hepatic fibrogenesis, which in turn facilitates the development of innovative therapies aimed at mitigating the impact of this devastating disease.

The book is organized into several chapters, each dedicated to exploring specific aspects of hepatic fibrogenesis. These chapters cover a broad spectrum of topics, including the role of inflammation in hepatic fibrosis, the involvement of epithelial-mesenchymal transition in tissue remodeling, and the molecular mechanisms underlying the activation of hepatic stellate cells. Additionally, the book discusses the role of genetic factors and epigenetic regulation in the development of hepatic fibrosis and explores the potential therapeutic implications of targeting these pathways.

Throughout the text, the authors employ clear and concise language, making complex scientific concepts accessible to a broad audience. Numerous illustrative figures and tables help to visualize the key concepts and provide a visual reference for readers. Furthermore, the book includes a comprehensive bibliography that serves as a valuable resource for further research and exploration of the field.

In conclusion, Hepatic Fibrosis: Mechanisms and Targets is a indispensable resource for researchers, physicians, and healthcare professionals seeking to gain a deeper understanding of hepatic fibrogenesis and develop effective therapies for this devastating disease. By providing a comprehensive and up-to-date exploration of the molecular and cellular mechanisms involved in fibrosis, this book serves as a valuable tool for advancing our knowledge in this field and ultimately improving patient outcomes.

Weight: 450g
Dimension: 235 x 191 (mm)
ISBN-13: 9780323997645