High-Throughput Screening Assays in Toxicology

The second edition of High Throughput Screening Assays in Modern Toxicology has been expanded to cover the latest advancements in HTS using in vitro, ex vivo, and in vivo models. It also includes the application of AI and data science to curate, manage, and use HTS data. The book is written in the Methods in Molecular Biology series format and is a valuable resource for scientists pursuing chemical toxicology research.

Format: Paperback / softback
Length: 200 pages
Publication date: 18 March 2023
Publisher: Springer-Verlag New York Inc.

This second edition volume expands on the previous edition by exploring the latest advancements in high throughput screening (HTS) in toxicity studies by using in vitro, ex vivo, and in vivo models. This volume also covers the application of artificial intelligence (AI) and data science to curate, manage, and use HTS data. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Cutting-edge and thorough, High Throughput Screening Assays in Modern Toxicology, Second Edition is a valuable resource for scientists pursuing chemical toxicology research. This book will aid scientists and researchers in translating new HTS techniques into standardized chemical toxicology assessment tools that can refine, reduce, and replace animal testing.

In vitro assays are used to evaluate the biological activity of chemicals in cell cultures, while ex vivo assays involve the use of animal or cell-based models to assess chemical toxicity. In vivo assays, on the other hand, involve the use of animals to evaluate the toxicity of chemicals.

High throughput screening (HTS) has revolutionized the field of chemical toxicology by allowing researchers to screen large numbers of chemicals in a relatively short period of time. HTS assays can be used to identify potential toxicants, evaluate the safety of chemicals, and develop new drugs and therapies.

One of the key advantages of HTS is that it can be used to screen a wide range of chemicals, including both natural and synthetic compounds. HTS assays can also be used to evaluate the toxicity of chemicals at different stages of development, including preclinical testing and clinical trials.

Another advantage of HTS is that it can be used to identify potential biomarkers of toxicity. Biomarkers are molecules that can be used to predict the toxicity of chemicals and to monitor the effects of chemical exposure in humans.

Artificial intelligence (AI) and data science are increasingly being used to curate, manage, and use HTS data. AI can be used to analyze large datasets and to identify patterns and relationships that may not be apparent to humans. Data science can be used to develop new algorithms and models that can improve the accuracy and efficiency of HTS assays.

In conclusion, High Throughput Screening Assays in Modern Toxicology, Second Edition is a comprehensive and up-to-date resource for scientists and researchers in the field of chemical toxicology. This book provides detailed information on the latest advancements in HTS in toxicity studies, including in vitro, ex vivo, and in vivo models. The book also covers the application of AI and data science to curate, manage, and use HTS data, which is essential for translating new HTS techniques into standardized chemical toxicology assessment tools. By using HTS assays, scientists and researchers can improve the efficiency and accuracy of chemical toxicology research, while reducing the need for animal testing.

Weight: 411g
Dimension: 254 x 178 (mm)
ISBN-13: 9781071622155
Edition number: 2nd ed. 2022