Human and Animal Filariases - Landscape, Challenges, and Control

Filariae are parasitic worms that infect animals and humans, causing severe diseases such as elephantiasis, river blindness, and heartworm disease. In 2017, the World Health Organization classified several filariases as neglected tropical diseases and announced a new program to eradicate them. Human and Animal Filariases provides a comprehensive approach to infections by filarial parasites, integrating current chemotherapy with recent advances in antifilarial drug discovery. It also offers practical information on assay development, target validation, and drug product profiles.

Format: Hardback
Length: 656 pages
Publication date: 14 December 2022
Publisher: Wiley-VCH Verlag GmbH

Filariae are a family of parasitic worms that infect animals and humans, causing severe diseases such as elephantiasis (lymphatic filariasis) and river blindness (onchocerciasis) in humans, as well as heartworm disease (dirofilariasis) in dogs and cats. While the human diseases are rarely fatal, the blindness and disfigurement resulting from these infections constitute a severe burden for the affected individuals and to the healthcare systems in many tropical countries. In 2017, the World Health Organization classified several filariases as neglected tropical diseases and announced a new program seeking to eradicate these infections, which has in turn sparked a new push to develop antifilarial drugs.

Considering the current and future import of this topic, Human and Animal Filariases takes a comprehensive look at infections by filarial parasites in humans and in animals. It begins by reviewing the current state of diagnosis and chemotherapy, before addressing the increasing resistance to available antifilarial drugs. This is followed by strategies and approaches for the discovery of novel drugs and finally by looking at alternative and supplementary approaches to combat the parasites, including vector control and vaccination.

Human and Animal Filariases readers will find:

A comprehensive approach that integrates current chemotherapy with recent advances in antifilarial drug discovery

Practical information on assay development, target validation, and required drug product profiles

Insights from global experts from leading academic institutions as well as from pharma and healthcare companies

Human and Animal Filariases is a unique resource for researchers, clinicians, and policymakers interested in filarial infections and their control.

Weight: 1188g
Dimension: 252 x 175 x 37 (mm)
ISBN-13: 9783527346592