Human Ocular Microbiome: Bacteria, Fungi and Viruses in the Human Eye

This book provides an integrated review of the human ocular microbiome, discussing its discovery, confounding factors, niche-specificity, core genera, dysbiosis, and functional relevance to ocular diseases. It also covers molecular mechanisms and microbiome-based therapies for treating ocular disorders.

Format: Hardback
Length: 290 pages
Publication date: 15 May 2022
Publisher: Springer Verlag, Singapore

This comprehensive book delves into the intricate world of the human ocular microbiome, offering a thorough examination of its composition and characteristics. It chronicles the groundbreaking discoveries made through traditional culturing methods and cutting-edge next-generation sequencing technologies, revealing the diverse array of ocular surface microbes present in both healthy and diseased eyes. The book goes beyond mere identification and explores the complex factors that shape the microbiome, mycobiome, and virome, including environmental influences, genetics, and immune responses.

The chapters delve into the specific niches of the ocular ecosystem, such as the skin, eyelid margins, and hands, highlighting the unique microbial communities associated with these areas. It introduces the concept of core genera, dysbiosis, and discriminating genera, shedding light on their roles in ocular diseases. The book also emphasizes the functional significance of the dysbiotic microbiome, mycobiome, and virome in the development and progression of ocular disorders, including dry eye and vernal keratoconjunctivitis.

Furthermore, the book explores the role of molecular mechanisms, including quorum-sensing and mucin metabolism, in ocular disorders such as dry eye. It discusses microbiome-based therapies as potential treatments for these conditions, highlighting the importance of understanding the microbiome in eye health and disease.

This book is a valuable resource for microbiologists, ophthalmologists, medical microbiology students, and medical practitioners alike. It provides a comprehensive understanding of the human ocular microbiome, its composition, functions, and implications for eye health and disease. By unraveling the mysteries of the ocular microbiome, this book lays the foundation for future research and therapeutic advancements in the field of ophthalmology.

Weight: 647g
Dimension: 235 x 155 (mm)
ISBN-13: 9789811917530
Edition number: 1st ed. 2022