Imidazole-Based Drug Discovery

Imidazole-Based Drug Discovery is a comprehensive book that covers imidazole and its derivatives, synthesis, pharmacological applications, and drug-based studies. It provides detailed coverage of greener synthetic protocols and pharmacological applications, making it an ideal resource for researchers in organic chemistry and medicinal chemistry.

Format: Paperback / softback
Length: 372 pages
Publication date: 06 December 2021
Publisher: Elsevier - Health Sciences Division

Imidazole-Based Drug Discovery encompasses a wide range of imidazole compounds and their derivatives, synthesis, pharmacological applications, and drug-based studies. Imidazole scaffolds serve as a bridge between organic synthesis and medicinal chemistry, encouraging researchers to explore innovative drug candidates. This comprehensive book offers detailed coverage of various greener synthetic protocols and pharmacological applications of imidazole derivatives, which are valuable to researchers working on developing more promising clinical lead compounds with this scaffold. Additionally, it provides insights into past decades of research on the synthesis and biological applications of imidazole derivatives. This book is an invaluable resource for researchers in organic chemistry, both in academic and industrial settings, as well as postgraduates in chemistry and medicinal chemistry.

Imidazole-Based Drug Discovery is a comprehensive and essential resource for researchers and practitioners in the field of organic chemistry, medicinal chemistry, and drug discovery. It provides detailed coverage of imidazole compounds and their derivatives, synthesis, pharmacological applications, and drug-based studies. The book highlights the importance of imidazole scaffolds in connecting organic synthesis and medicinal chemistry, leading to the exploration of innovative drug candidates.

The book begins by introducing the basic properties and synthesis of imidazole compounds, including their structural characteristics, reactivity, and applications in various fields. It then delves into the synthesis of imidazole derivatives, including methods such as direct synthesis, microwave-assisted synthesis, and heterocyclic synthesis. The authors discuss the pharmacological properties of imidazole derivatives, including their anticancer, antimicrobial, and anti-inflammatory activities, as well as their potential applications in the treatment of diseases such as cancer, tuberculosis, and HIV/AIDS.

In addition to synthesis and pharmacology, the book also provides detailed coverage of drug-based studies involving imidazole compounds. It discusses the use of imidazole derivatives as scaffolds for drug discovery, the development of novel drug delivery systems, and the evaluation of drug efficacy and safety in preclinical and clinical studies. The authors also provide insights into the challenges and opportunities associated with imidazole-based drug discovery, including the need for efficient synthesis protocols, the development of novel drug targets, and the optimization of drug formulations.

The book is organized into five chapters, each covering a different aspect of imidazole-based drug discovery. The first chapter provides an overview of imidazole compounds and their derivatives, including their structural characteristics, reactivity, and applications. The second chapter focuses on the synthesis of imidazole derivatives, including various methods and strategies employed in the synthesis process. The third chapter discusses the pharmacological properties of imidazole derivatives, including their anticancer, antimicrobial, and anti-inflammatory activities. The fourth chapter explores drug-based studies involving imidazole compounds, including scaffold-based drug discovery, drug delivery systems, and drug evaluation. The fifth chapter provides insights into the challenges and opportunities associated with imidazole-based drug discovery, including future directions for research and development.

Overall, Imidazole-Based Drug Discovery is a valuable resource for researchers and practitioners in the field of organic chemistry, medicinal chemistry, and drug discovery. It provides comprehensive coverage of imidazole compounds and their derivatives, synthesis, pharmacological applications, and drug-based studies. The book is well-written, accessible, and informative, making it an essential tool for anyone interested in exploring the potential of imidazole-based drugs in the treatment of diseases.

Weight: 450g
Dimension: 229 x 152 (mm)
ISBN-13: 9780323854795