Immunology of Recurrent Pregnancy Loss and Implantation Failure

The book "Immunology of Recurrent Pregnancy Loss" provides doctors and immunologists with information to help couples who experience recurrent pregnancy losses. It covers unexplained infertility, repeated IVF, embryo transfer failures, and pregnancy with a history of autoimmune and/or alloimmune disease.

Format: Paperback / softback
Length: 456 pages
Publication date: 07 July 2022
Publisher: Elsevier Science & Technology

Immunology of Recurrent Pregnancy Loss is a comprehensive resource for doctors and immunologists seeking to assist couples experiencing recurrent pregnancy losses. The book covers various topics related to reproductive failure, including unexplained infertility, repeated in vitro fertilization (IVF) attempts, embryo transfer failures, history of second or third trimester pregnancy losses of unknown cause, and pregnancies with a history of or active autoimmune and/or alloimmune disease.

Reproductive failure, encompassing recurrent pregnancy losses (RPL) and repeated implantation failures (RIF), is a complex syndrome driven by a multitude of etiologies, including anatomical, endocrine, genetic, infectious, immunological, thrombotic, and unexplained factors. This book aims to provide the most up-to-date information on reproductive immunology in the context of RF. Divided into five sections, the book offers a systematic approach to diagnosing and treating reproductive immunological disorders.

In the first section, "Unexplained Infertility," the book explores the underlying causes of unexplained infertility, including genetic abnormalities, endometrial factors, and immune disorders. It provides detailed diagnostic guidelines and discusses the role of immunological testing in identifying immune-related causes of infertility.

The second section, "Repeated IVF Attempts," delves into the factors that can contribute to IVF failures, such as poor embryo quality, hormonal imbalances, and immune-related complications. It offers insights into immune-modulating therapies and strategies to enhance IVF success rates.

The third section, "Embryo Transfer Failures," explores the immune-mediated mechanisms that can lead to embryo implantation failure. It discusses the role of immune cells, cytokines, and antibodies in embryo implantation and provides diagnostic guidelines for immune-related embryo transfer failures.

The fourth section, "History of Second or Third Trimester Pregnancy Losses of Unknown Cause," focuses on the investigation of pregnancy losses in the second or third trimester without a clear etiology. It discusses the use of immunological testing, including antibody screening, to identify potential immune-related causes of these losses.

The fifth section, "Pregnancy with a History of or Active Autoimmune and/or Alloimmune Disease," addresses the impact of autoimmune and alloimmune diseases on pregnancy outcomes. It provides detailed information on the diagnosis and management of autoimmune and alloimmune disorders during pregnancy, including immunosuppressive therapies and pregnancy-specific management strategies.

Throughout the book, the authors emphasize the importance of a multidisciplinary approach to the treatment of reproductive immunological disorders. They highlight the significance of collaboration between reproductive endocrinologists, immunologists, and other healthcare professionals to provide comprehensive care to couples experiencing RF.

Immunology of Recurrent Pregnancy Loss is a valuable resource for doctors and immunologists seeking to improve their understanding of reproductive immunology and provide optimal care to couples facing reproductive challenges. With its comprehensive coverage of topics, systematic diagnostic guidelines, and therapeutic approaches, the book empowers practitioners to address the complex etiologies of RF and enhance pregnancy outcomes for their patients.

Weight: 922g
Dimension: 190 x 233 x 26 (mm)
ISBN-13: 9780323908054