Integrins in Health and Disease: Key Effectors of Cell-Matrix and Cell-Cell Interactions

Integrins are heterodimeric cell surface receptors that play pivotal roles in physiological and pathological processes, including tissue morphogenesis, wound healing, and cell growth. This book provides a summary of the most important integrins and their biological functions, including knockout- and animal models, pathological tissue remodeling, and the immune system. It is authoritative, easily accessible, and informative for researchers and clinicians.

Format: Hardback
Length: 472 pages
Publication date: 11 March 2023
Publisher: Springer International Publishing AG

Integrins are a class of heterodimeric cell surface receptors that play a crucial role in anchoring cells to various extracellular matrix proteins and facilitating cell-cell interactions. These versatile proteins are involved in a wide range of physiological processes, including tissue morphogenesis, wound healing, and cell growth regulation. Moreover, integrins also play a significant role in numerous pathological conditions, such as autoimmunity, infectious diseases, and carcinogenesis.

This comprehensive book aims to provide readers with a comprehensive overview of the most important integrins and their biological functions. It begins by introducing the structure and function of integrins and discussing their role in cell adhesion and signaling. The book then delves into the study of knockout and animal models to understand the functionality of key collagen-, laminin-, and nephronectin-binding integrins.

Furthermore, the book explores the role of integrins in pathological tissue remodeling, particularly in joints and cardiac tissue. Reviews of the current knowledge on the role of integrins in tissue and tumor fibrosis, angiogenesis, and tumor progression are included, providing insights into the mechanisms underlying these processes.

The book also discusses the immune system's role in regulating integrin-ligand interactions and the use of antibodies to target these interactions. Additionally, it explores the role of integrins as receptors for bacterial and viral cell invasion, highlighting their potential as targets for therapeutic interventions.

With its authoritative content, easily accessible format, and vast informative coverage, "Integrins in Health and Disease - Key Effectors of Cell-Matrix and Cell-Cell Interactions" is an invaluable resource for both experienced researchers and clinicians, as well as PhD students interested in studying the extracellular matrix and cell adhesion molecules. The book is part of the Biology of Extracellular Matrix series, published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.

Weight: 887g
Dimension: 235 x 155 (mm)
ISBN-13: 9783031237805
Edition number: 1st ed. 2023