Investigating Human Diseases with the Microbiome: Metagenomics Bench to Bedside

Investigating Human Diseases with the Microbiome: Metagenomics Bench to Bedside is a reference that summarizes the underlying principles for human health and disease studies from a microbiome point-of-view. It explains that microbiomes in fecal, oral/nasal, vaginal, and skin samples contain important information that can predict disease risks in the future, and that tissue samples also contain microbes that are relevant for diseases. The microbiome connects genetic and environmental factors and is poised to facilitate precision medicine, including prevention, diagnosis, and effective treatment of many complex diseases.

Format: Paperback / softback
Length: 226 pages
Publication date: 28 February 2022
Publisher: Elsevier Science & Technology

Investigating Human Diseases with the Microbiome: Metagenomics Bench to Bedside is a comprehensive overview of fundamental principles for understanding human health and disease from a microbiome perspective. Throughout an individual's lifespan, the microbiomes present in various bodily samples, such as fecal, oral/nasal, vaginal, and skin samples, hold invaluable information that can predict future disease risks. Tissue samples also harbor microorganisms that are relevant to various diseases. The microbiome serves as a bridge between genetic and environmental factors, holding immense potential to revolutionize precision medicine. This reference, rooted in traditional microbiology and incorporating a holistic view of high-throughput sequencing, addresses key questions regarding the total number of microbial cells and their distribution within the human body. It also considers concepts from macroecology and causal reasoning. An entire chapter is dedicated to methods, offering practical guidance for crucial considerations when collecting samples for metagenomic studies.

Weight: 476g
Dimension: 233 x 190 x 18 (mm)
ISBN-13: 9780323913690