Ion and Molecule Transport in Lysosomes

Lysosomes are essential subcellular organelles that regulate cell function, and their dysfunction is linked to multiple diseases. This book discusses concepts and methods used to study lysosome ion and small molecule transport, attracting accomplished investigators and trainees.

Format: Paperback / softback
Length: 252 pages
Publication date: 01 February 2022
Publisher: Taylor & Francis Ltd

Lysosomes are essential subcellular organelles that play a vital role in regulating cellular functions. These tiny structures are responsible for carrying out numerous essential activities within cells, making them indispensable for maintaining cellular homeostasis. Dysfunction in lysosomes is linked to a wide range of diseases, including storage disorders, neurodegeneration, immunological diseases, and cancer.

In this comprehensive book, we delve into the concepts and methods used to study lysosome ion and small molecule transport. The contents of this book are designed to appeal to a diverse audience, including accomplished investigators seeking a broad review and synthesis of this important subject, as well as young investigators and trainees who need to acquire comprehensive knowledge and technical skills in working with lysosomal ion channels and small molecule transporters.

Lysosomes are responsible for the degradation and recycling of cellular waste, including damaged organelles, proteins, and other macromolecules. They also play a crucial role in digesting ingested substances and generating energy through the process of cellular respiration. The malfunctioning of lysosomes can lead to the accumulation of undigested waste, which can cause cellular damage and inflammation.

One of the key areas of research in lysosome biology is the study of lysosome ion channels and small molecule transporters. These proteins are essential for the transport of ions and small molecules across the lysosomal membrane, which is crucial for the proper functioning of lysosomes. Dysfunction in these transport proteins can result in a variety of diseases, including cystic fibrosis, Gaucher disease, and Parkinson's disease.

The book discusses the structure, function, and regulation of lysosome ion channels and small molecule transporters. It provides detailed information on the mechanisms by which these proteins are synthesized, trafficked, and degraded within cells. The authors also explore the role of lysosome-related proteins in the pathogenesis of diseases, including their involvement in the clearance of toxic substances, the regulation of cellular signaling, and the maintenance of cellular homeostasis.

In addition to discussing the basic biology of lysosomes, the book also provides insights into the latest technologies and methods used in lysosome research. These include techniques such as fluorescence microscopy, electron microscopy, genetic engineering, and mass spectrometry, which allow researchers to study lysosome dynamics, structure, and function in unprecedented detail. The authors also discuss the applications of these technologies in drug discovery, disease diagnosis, and the development of new therapies for lysosome-related diseases.

Overall, this book is a valuable resource for researchers, students, and clinicians interested in lysosome biology and related fields. It provides a comprehensive overview of lysosome function, dysfunction, and the latest research techniques used to study these important organelles. By exploring the contents of this book, readers will gain a deeper understanding of the role that lysosomes play in maintaining cellular health and the potential for developing new therapies for lysosome-related diseases.

Weight: 467g
Dimension: 234 x 156 (mm)
ISBN-13: 9781032241159