Ion Channels: Channel Chemical Biology, Engineering, and Physiological Function

The Methods in Enzymology series, Ion Channels, Part C, Volume 653, highlights new advances in the field, including Nonsense suppression in ion channels, Engineering Ion Channels Using Protein Trans-splicing, Probing Ion Channel Neighborhoods Using APEX, STX-based probes for NaVs, ANAP: a versatile fluorescent probe of ion channel gating and regulation, High Throughput Screens for Small Molecule Ion Channel Modulators, Using toxins to study ion channels, Re/de-constructing ubiquitin regulation of ion channels, Tethered Peptide Toxins for Ion Channels, Voltage-Sensing Phosphatase Molecular Engineering, and more. Additional chapters cover Engineering excitable cells, Stretch and Poke Stimulation of Mechanically-Activated Ion Channels, Optical Control of STIM Channels, High Throughput Electrophysiological Evaluation of Mutant Ion Channels, Evaluating BEST1 Mutations in RPE Stem Cells, Long Read Transcript Profiling of Ion Channel Splice Variants, Permeation of Connexin Channels, Ratiometric pH indicator for melanosomes and lysosomes, and Ion channels in the epithelial cells of the choroid plexus.

Format: Hardback
Length: 446 pages
Publication date: 15 June 2021
Publisher: Elsevier Science Publishing Co Inc

The Methods in Enzymology series, Ion Channels, Part C, Volume 653, presents a comprehensive and up-to-date overview of the latest advancements in the field. This new volume offers a diverse range of captivating chapters on various topics, such as Nonsense Suppression in Ion Channels, Engineering Ion Channels Using Protein Trans-splicing, Probing Ion Channel Neighborhoods Using APEX, STX-based Probes for NaVs, ANAP: a Versatile, Fluorescent Probe of Ion Channel Gating and Regulation, High Throughput Screens for Small Molecule Ion Channel Modulators, Using Toxins to Study Ion Channels, Re/de-constructing Ubiquitin Regulation of Ion Channels, Tethered Peptide Toxins for Ion Channels, Voltage-Sensing Phosphatase Molecular Engineering, and much more.

In addition to these core chapters, the book includes additional chapters that cover essential aspects of ion channel research. These chapters include Engineering Excitable Cells, Stretch and Poke Stimulation of Mechanically-Activated Ion Channels, Optical Control of STIM Channels, High Throughput Electrophysiological Evaluation of Mutant Ion Channels, Evaluating BEST1 Mutations in RPE Stem Cells, Long Read Transcript Profiling of Ion Channel Splice Variants, Permeation of Connexin Channels, Ratiometric pH Indicator for Melanosomes and Lysosomes, and Ion Channels in the Epithelial Cells of the Choroid Plexus.

By compiling these diverse and informative chapters, the Methods in Enzymology series provides researchers and students with a valuable resource for understanding the complexities of ion channel function and regulation. The book's extensive coverage of cutting-edge techniques and technologies makes it an essential tool for advancing our knowledge in this field and facilitating future research endeavors.

Weight: 860g
Dimension: 229 x 152 (mm)
ISBN-13: 9780128239247