Ionizing Radiation and the Immune Response - Part A

Ionizing Radiation and the Immune Response,Volume 376,Part A discusses the latest updates on the immune response induced by ionizing radiations, including NK functions, TRT, radio-induced immune response, lipid metabolism, protons, heavy ions, flashtherapy, mini beam, radio-induced lymphopenia, CT to potentiate radio-induced immune response, impact of RT on healthy tissues, radio-induced macrophagic response, nanoparticles, and ionizing radiations to modulate immune response, low dose radiation on radio-induced immune response, role of Dendritic cells, and biomarkers of radiation-induced response to optimize radio-immunotherapy combination.

Format: Hardback
Length: 184 pages
Publication date: 01 May 2023
Publisher: Elsevier Science & Technology

Ionizing Radiation and the Immune Response,Volume 376,Part A provides a comprehensive review of the latest advancements in understanding the immune response triggered by ionizing radiations. The book is divided into several sections, each exploring different aspects of this topic.

In the first section, NK Functions in Radio-Induced Immune Response, the authors delve into the role of natural killer cells (NK cells) in the immune response to radio-induced damage. NK cells are crucial in detecting and eliminating abnormal cells, and their activation is a key mechanism in the defense against radiation-induced tumors. The section discusses the mechanisms by which NK cells are activated and the implications of their activation for radiation therapy.

The second section, TRT and Immune Response, explores the effects of testosterone replacement therapy (TRT) on immune function. TRT has been shown to improve immune responses in older men with low testosterone levels, and the section discusses the potential implications of this therapy for radiation-induced immune suppression.

Radio-Induced Immune Response and Lipid Metabolism examines the relationship between radiation-induced immune suppression and lipid metabolism. Lipids play a crucial role in immune cell function, and the section explores how radiation can alter lipid metabolism and the potential implications for immune response.

Effect of Protons and Heavy Ions on Immune Response explores the effects of protons and heavy ions on immune cell function and the immune response to radiation. Protons and heavy ions have unique biological properties that can affect immune cells differently, and the section discusses the potential benefits and risks of using these particles in radiation therapy.

Effect of Flashtherapy and Mini Beam on Immune Response examines the use of flashtherapy and mini beam radiation therapy in modulating the immune response. These therapies are designed to target specific immune cells and stimulate their activation, potentially improving the efficacy of radiation therapy.

Radio-Induced Lymphopenia, CT to Potentiate Radio-Induced Immune Response, and Impact of RT on Healthy Tissues (Inflammation) explore the effects of radiation on lymphocyte populations and the potential use of CT scans to enhance the immune response. Radiation can cause lymphopenia, which can impair immune function, and the section discusses the use of CT scans to identify areas of radiation damage and potentially improve the immune response.

Radio-Induced Macrophagic Response examines the role of macrophages in the immune response to radiation. Macrophages are important in clearing debris and promoting healing, and the section discusses the potential benefits and risks of using radiation to stimulate macrophage activity.

To Use Nanoparticles and Ionizing Radiations to Modulate Immune Response: Opinion of the Chemist, Biologist, and Clinician explores the potential use of nanoparticles and ionizing radiations to modulate immune response. Nanoparticles have been shown to have immunomodulatory properties, and the section discusses the potential applications of these particles in radiation therapy.

Additional sections touch on the Effect of Low Dose Radiation on Radio-Induced Immune Response, Role of Dendritic Cells in Radiation-Induced Immune Response, Relationship between the Tumor Microenvironment and the Efficacy of the Radiotherapy/Immunotherapy Combination+, and Biomarkers of Radiation-Induced Response to Optimize Radio-Immunotherapy Combination.

These sections provide a comprehensive overview of the latest research in the field of ionizing radiation and the immune response. The book is a valuable resource for researchers, clinicians, and healthcare professionals interested in understanding the immune response to radiation and developing new therapies to improve treatment outcomes.

Weight: 450g
Dimension: 229 x 152 (mm)
ISBN-13: 9780323955232