Mammalian Heme Peroxidases: Diverse Roles in Health and Disease

Mammalian heme peroxidases are crucial for innate immune responses and disease prevention,but their overproduction can contribute to chronic inflammatory conditions. Peroxidasins,a protein family related to heme peroxidases,play a novel role in tissue biogenesis and matrix assembly. This book explores recent developments in our understanding of these enzymes and their associated oxidants,their involvement in innate immunity and chronic inflammatory disease,and potential therapeutic approaches to modulate and prevent damaging reactions.

Format: Paperback / softback
Length: 328 pages
Publication date: 29 January 2024
Publisher: Taylor & Francis Ltd

Mammalian heme peroxidases are crucial enzymes in innate immune responses and disease prevention. They produce powerful chemical oxidants that play a vital role in safeguarding the body against pathogens. While these oxidants are highly beneficial in immune defense, it is now widely recognized that overproduction of peroxidases contributes to the initiation and persistence of various chronic inflammatory conditions in different organs such as the cardiovascular, neurological, respiratory, renal, and gastrointestinal systems.

Peroxidasins, a protein family related to heme peroxidases, have emerged as important players in tissue biogenesis and matrix assembly. Their roles in these processes are gaining attention in various pathological contexts. Understanding the chemistry, biochemistry, and biological functions of mammalian peroxidases and their associated oxidants is essential for developing therapeutic strategies to modulate and prevent harmful reactions.

This book provides a comprehensive overview of recent developments in our understanding of mammalian peroxidases and their associated oxidants. It covers their structure and biosynthesis, reactivity with biological substrates, roles in innate immunity, and their involvement in chronic inflammatory diseases in various end organs. The book also explores potential therapeutic approaches to modulate peroxidase activity and prevent damaging reactions.

By delving into these aspects, this book offers valuable insights into the complex roles of mammalian heme peroxidases and their potential applications in the field of medicine. It is a valuable resource for researchers, clinicians, and healthcare professionals interested in inflammation, immune responses, and disease prevention.

Weight: 453g
Dimension: 254 x 178 (mm)
ISBN-13: 9781032079646