Mass Spectrometry-Based Glycoproteomics and Its Clinic Application

Glycosylation is a crucial protein post-translational modification that plays a vital role in regulating organisms and is associated with various physiological and pathological processes. MS-based glycoproteomic analysis is a powerful tool used to study glycoproteins and glycans. This book reviews advancements achieved in MS-based glycoproteomic analysis, including selective enrichment, qualitative, quantitative, and data analysis, and their clinical applications. It will serve as a valuable resource for students, postdocs, and researchers working in proteomics, glycoscience, analytical chemistry, biochemistry, and clinical medicine.

Format: Hardback
Length: 248 pages
Publication date: 20 September 2021
Publisher: Taylor & Francis Ltd

Glycosylation, a crucial protein post-translational modification, holds immense significance in regulating organisms and is intricately linked to diverse physiological and pathological processes. In recent years, researchers have dedicated significant attention to characterizing protein glycosylation sites, structures, and their extent of modification, with the aim of better understanding their biological roles and exploring potential biomarkers for disease diagnosis and treatment.

Mass spectrometry (MS) stands as a powerful tool in the study of biomolecules, including glycoproteins and glycans. The field of glycoproteomics and glycomics, driven by MS analysis, has witnessed remarkable advancements, leading to the development of various analytical methodologies and strategies for selective enrichment. These techniques have played a pivotal role in unraveling the structure and function of glycoproteins and glycans.

In this comprehensive book, titled "Mass Spectrometry–Based Glycoproteomics and Its Clinic Application," the authors present a detailed review of advancements achieved in MS-based glycoproteomic analysis. The book encompasses a wide range of analytical methodologies and strategies, including selective enrichment, qualitative, quantitative, and data analysis, along with their clinical applications. Significant examples are provided to illustrate the principles, laboratory protocols, and practical advice for successful implementation, ensuring robust and reliable results.

The book is particularly valuable for students, postdocs, and researchers engaged in proteomics, glycoscience, analytical chemistry, biochemistry, and clinical medicine. It serves as a comprehensive resource that elucidates new techniques and their applications, facilitating the exploration of glycoprotein-related research and its translation into clinical practice.

Editor: Haojie Lu, a professor at Fudan University, specializes in proteomics based on mass spectrometry, with a particular emphasis on novel technologies for separation and identification of low-abundant proteins and post-translationally modified proteins, including glycosylation. His extensive expertise and contributions to the field make him an ideal editor for this book.

In conclusion, "Mass Spectrometry–Based Glycoproteomics and Its Clinic Application" is a vital resource for researchers and practitioners seeking to advance their understanding of glycoproteins and glycans. By presenting cutting-edge techniques and their clinical applications, this book empowers scholars and practitioners to unravel the complexities of glycosylation and its implications in various biological contexts. It is a must-read for anyone interested in glycoproteomics and its potential applications in medicine.

Weight: 635g
Dimension: 229 x 152 (mm)
ISBN-13: 9781032028613