Matrix Pathobiology and Angiogenesis

The extracellular matrix (ECM) is crucial for regulating angiogenesis, vascular mechanosensing, and blood vessel stability. This book provides an overview of the ECM's roles in these processes and discusses its importance for maintaining vascular integrity, capillary and arterial morphogenesis, and lymphangiogenesis. It also explores the regulation of endothelial cell and pericyte functions by the ECM under physiological and pathological conditions and discusses approaches to exploit ECM molecules for designing therapeutic approaches or as biomarkers to improve therapeutic decisions.

Format: Hardback
Length: 320 pages
Publication date: 20 December 2022
Publisher: Springer International Publishing AG

The extracellular matrix (ECM) plays a crucial role in the regulation of angiogenesis, vascular mechanosensing, and blood vessel stability within the vasculature. This comprehensive book aims to provide a thorough understanding of the diverse functions of the ECM during angiogenesis, emphasizing its vital role in maintaining vascular integrity, promoting capillary and arterial morphogenesis, and facilitating lymphangiogenesis. Furthermore, it delves into the mechanisms by which the ECM regulates endothelial cell and pericyte functions under both physiological and pathological conditions.

In addition, the reader will gain insights into various approaches employed to exploit ECM molecules for the development of therapeutic strategies or as biomarkers to enhance therapeutic decision-making. With its extensive coverage and cutting-edge insights, Matrix Pathobiology and Angiogenesis serves as a valuable resource for experienced researchers and early career scientists seeking to delve deeper into this exciting and rapidly evolving field.

This book is part of the prestigious Biology of Extracellular Matrix series, which is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.

Weight: 688g
Dimension: 235 x 155 (mm)
ISBN-13: 9783031196157
Edition number: 1st ed. 2023