Metabolic Engineering: Concepts and Applications

Metabolic Engineering: Concepts and Applications is a comprehensive resource that provides a complete description of the concepts, models, and applications of metabolic engineering. It covers foundational and advanced topics, including metabolic engineering of major cell lines, organisms, and microbiome engineering, and offers practical insights into pathway design, metabolomics, and genome editing. The book is written for students of biotechnology, bioengineers, and biotechnologists and is useful for practicing biotechnologists and bioengineers who wish to solidify their understanding of the field.

Format: Hardback
Length: 976 pages
Publication date: 23 June 2021
Publisher: Wiley-VCH Verlag GmbH

Metabolic engineering is a rapidly evolving field that encompasses the design, manipulation, and optimization of biological systems for various purposes, such as producing biofuels, developing new medicines, and improving agricultural productivity. This comprehensive resource, edited by esteemed leaders in the field, provides a comprehensive overview of foundational and advanced topics in metabolic engineering.

Part 1: Essential Models and Strategies

Metabolic Engineering: Concepts and Applications begins by introducing the essential models and strategies employed in the field. These include Flux Balance Analysis, which helps to understand the flow of metabolites within a system; Quantitative Flux Analysis, which provides a more detailed analysis of metabolic pathways; and Proteome Constrained Models, which take into account the protein content of a cell.

The book also provides an overview of topics such as pathway design, metabolomics, and genome editing of bacteria and eukarya. These topics are crucial in understanding the structure and function of metabolic pathways and their potential for modification.

Part 2: Practical Applications

The second part of the book focuses on the practical applications of metabolic engineering. It provides insightful descriptions of the metabolic engineering of major cell lines, including Escherichia coli, Bacillus, and Yarrowia lipolytica. These cell lines are widely used in various industries, such as biotechnology and pharmaceuticals, and their metabolic pathways can be manipulated to enhance desired products.

The book also discusses the metabolic engineering of organisms, including human, animal, and plant. This includes the development of new biofuels, the production of therapeutic compounds, and the improvement of agricultural productivity. Metabolic engineering techniques such as gene expression manipulation, metabolic pathway optimization, and synthetic biology are used to achieve these goals.

In addition to these topics, the book also provides an in-depth treatment of the thermodynamics of metabolic pathways, which is essential for understanding the energy requirements and limitations of biological systems. It also discusses the genome architecture of E. coli, as well as genome editing of both bacteria and eukarya.

Metabolic engineering is a multidisciplinary field that requires expertise from various fields, such as biology, chemistry, and engineering. This resource is designed to be accessible to students of biotec, providing them with a comprehensive understanding of the field and its potential applications.

In conclusion, Metabolic Engineering: Concepts and Applications is a valuable resource for anyone interested in metabolic engineering. It provides a comprehensive overview of foundational and advanced topics, practical applications, and resources for further study. With its expert editors and insightful descriptions, this book is an essential tool for students, researchers, and professionals in the field.

Weight: 2120g
Dimension: 255 x 178 x 56 (mm)
ISBN-13: 9783527346622