Microneedles

Microneedles is a book that explores the design, fabrication, and use of microneedles for drug and vaccine delivery, discussing the contemporary status of the field and providing a detailed discussion of their use in diagnostics.

Format: Paperback / softback
Length: 264 pages
Publication date: 10 February 2022
Publisher: Elsevier Science & Technology

Microneedles is a comprehensive exploration of the design, fabrication, and practical applications of microneedles in drug and vaccine delivery. This book delves into the current state of the field, providing detailed insights into various aspects, including the diverse types of microneedles such as dissolving, solid, coted, hollow, and hydrogel-forming. Additionally, it offers a comprehensive anatomical description of the eye to enhance understanding of microneedle-assisted ocular drug delivery. Furthermore, the book comprehensively addresses the use of microneedles in diagnostics, with a dedicated chapter dedicated to mathematical modeling of microneedle-mediated drug delivery. Given the versatility of microneedles, which can be utilized by researchers in both academia and industry, this book is an invaluable resource for regulatory scientists and graduate students who are interested in this field.

Microneedles, tiny needles with a diameter ranging from a few micrometers to several millimeters, have gained significant attention in recent years for their potential in drug and vaccine delivery. Their unique properties, including their ability to penetrate the skin and deliver drugs directly into the bloodstream, make them an attractive alternative to traditional injection methods. In this book, we will explore the design, fabrication, and use of microneedles for drug and vaccine delivery. We will begin by discussing the contemporary status of the field, including the different types of microneedles available and their applications in drug delivery. We will then delve into the anatomy of the eye, which is crucial for understanding microneedle-assisted ocular drug delivery. Finally, we will discuss the use of microneedles in diagnostics, with a focus on mathematical modeling of microneedle-mediated drug delivery.

Microneedles are made from various materials, including metals, polymers, and ceramics. The choice of material depends on the intended application and the properties required for the microneedle. For drug delivery, microneedles can be designed to dissolve or release the drug upon penetration into the skin. This allows for a controlled and targeted release of the drug, minimizing side effects and improving patient compliance. Solid microneedles, on the other hand, can be used to deliver vaccines or other biomaterials directly into the skin. These microneedles can be designed to release the vaccine or biomaterial slowly over time, allowing for a sustained immune response.

One of the key advantages of microneedles is their ability to penetrate the skin deeply. This allows for the delivery of drugs to the target tissues, such as the muscles, liver, or brain, where they can exert their therapeutic effects. Microneedles can also be used to deliver vaccines to hard-to-reach areas, such as the inner ear or the back of the throat. In addition, microneedles can be used to deliver drugs to the skin in a non-invasive manner, reducing the risk of infection and scarring.

However, the use of microneedles also presents several challenges. One of the main challenges is the safety of microneedles. Since microneedles are inserted into the skin, there is a risk of infection or injury. To address this issue, researchers have developed various safety measures, such as sterilization of the microneedles and the use of non-toxic materials. Another challenge is the stability of the drug payload within the microneedle. The drug payload can degrade or be released prematurely, which can reduce the effectiveness of the drug delivery. To address this issue, researchers have developed various packaging materials and delivery mechanisms to ensure the stability of the drug payload.

In conclusion, microneedles are a promising technology for drug and vaccine delivery. Their unique properties, including their ability to penetrate the skin and deliver drugs directly into the bloodstream, make them an attractive alternative to traditional injection methods. However, the use of microneedles also presents several challenges, which must be addressed to ensure the safety and effectiveness of this technology. With continued research and development, microneedles have the potential to revolutionize the field of drug delivery and improve patient outcomes.

Weight: 440g
Dimension: 153 x 229 x 25 (mm)
ISBN-13: 9780323918114