MicroRNA in Human Malignancies

MicroRNA in Human Malignancies is a comprehensive book that explores the role and translational significance of miRNAs in cancer and other malignancies. It covers essential mechanisms, metabolic pathways, and therapeutic opportunities, making it a valuable resource for students, researchers, and investigators.

Format: Paperback / softback
Length: 432 pages
Publication date: 17 February 2022
Publisher: Elsevier Science Publishing Co Inc

MicroRNAs in Human Malignancies provides a comprehensive exploration of the crucial role and translational significance of microRNAs (miRNAs) in the progression of cancer and other malignancies. The book establishes the foundations of the field by delving into essential mechanisms and the immense translational potential of miRNAs in the realm of oncology. Specific topics covered include the intricate mechanisms of invasion and metastasis, the interplay between miRNAs and metabolism, and the promising opportunities presented by miRNAs in the field of therapeutics. Each chapter focuses on a particular disease, providing in-depth insights into disease-related pathophysiology, as well as the diagnostic, prognostic, and predictive value of miRNAs. This comprehensive text serves as an indispensable resource for students embarking on their journey into the field of oncology, as well as researchers and investigators seeking to advance their understanding of these vital molecules.

Introduction:
MicroRNAs (miRNAs) are small non-coding RNAs that play a pivotal role in regulating gene expression and cellular processes. Their involvement in cancer development and progression has gained significant attention in recent years. In this book, we will delve into the role of miRNAs in human malignancies, exploring their mechanisms, functions, and potential therapeutic applications.
Mechanisms of MicroRNA Action:
miRNAs function by binding to specific messenger RNA (mRNA) sequences, either complementary or partially complementary, and inhibiting their translation or promoting their degradation. This regulation can occur at multiple stages of the gene expression pathway, including transcription, splicing, and translation. The specific binding of miRNAs to their target mRNAs determines their regulatory effects, which can range from silencing genes to promoting their expression.
Translational Significance of MicroRNAs in Cancer:
miRNAs are highly expressed in cancer cells compared to normal cells, and their dysregulation is associated with various cancer-related phenotypes. They can act as oncogenes or tumor suppressors, regulating the expression of genes involved in cell growth, survival, invasion, and metastasis. For example, miRNAs can target tumor suppressor genes, leading to their inactivation, while they can also target oncogenes, promoting their expression and contributing to cancer development.
MicroRNAs and Metabolism:
miRNAs also play a significant role in metabolism, regulating the expression of genes involved in energy production, lipid metabolism, and drug metabolism. Dysregulation of these metabolic pathways can contribute to cancer development and progression. For instance, miRNAs can regulate the expression of enzymes involved in fatty acid synthesis, leading to the accumulation of lipids in cancer cells, which can promote tumor growth and metastasis.
Opportunities for MicroRNAs in Therapeutics:
The potential of miRNAs as therapeutic agents is being explored extensively. miRNAs can be used as biomarkers to diagnose and predict cancer outcomes, as well as targets for therapeutic interventions. For example, miRNAs can be delivered to cancer cells using nanoparticles or other delivery vehicles, which can inhibit the expression of specific oncogenes or promote the expression of tumor suppressor genes.
Chapters on Diseases:
The book includes chapters on various diseases, including breast cancer, lung cancer, colorectal cancer, and leukemia. Each chapter provides an overview of the disease-related pathophysiology, as well as the diagnostic, prognostic, and predictive value of miRNAs. The information presented in these chapters is based on the latest research and clinical evidence, providing valuable insights for researchers and clinicians.
Conclusion:
MicroRNAs in Human Malignancies offers a comprehensive and up-to-date overview of the role and translational significance of miRNAs in cancer development and other malignancies. The book provides valuable insights for students, researchers, and clinicians interested in understanding the molecular mechanisms underlying cancer and developing new therapeutic strategies. By unraveling the complexities of miRNA regulation and their impact on cancer, this book contributes to the ongoing efforts to combat this devastating disease.

Weight: 450g
Dimension: 235 x 191 (mm)
ISBN-13: 9780128222874