Mineralizing Vesicles: From Biochemical and Biophysical Properties to Their Roles in Physiology and Disease

Mineralizing Vesicles: From Biochemical and Biophysical Properties to Their Roles in Physiology and Disease covers the state-of-the-art in the properties of mineralizing EVs and their potential clinical applications. It discusses the biochemical and biological aspects of EVs, their role in bone ossification, cardiovascular, and cartilage-related diseases, and the enzymes catalysing inorganic phosphate and calcium turnover. It also covers the role of autophagy and the lumen of mineralizing EVs filled with miRNA. The book provides practical aspects of working with mineralizing EVs, including purification, proteomic and biophysical analyses, and their use in regenerative medicine.

Format: Paperback / softback
Length: 446 pages
Publication date: 30 November 2023
Publisher: Elsevier Science & Technology

Mineralizing Vesicles: From Biochemical and Biophysical Properties to Their Roles in Physiology and Disease

Mineralizing extracellular vesicles (EVs) are a class of vesicles that play crucial roles in various physiological processes and diseases. In this comprehensive book, experts in the field present the latest advancements in understanding the properties of mineralizing EVs and their potential clinical applications.

The first chapter provides a foundational understanding of EVs, covering their biochemical and biological aspects. It explores the composition, structure, and functions of these vesicles, as well as their role in cell communication and tissue homeostasis.

The second chapter delves into the role of mineralizing EVs in bone ossification and cardiovascular and cartilage-related diseases. It highlights the unique ability of these vesicles to form apatite minerals, which are essential for bone formation and tooth development. The chapter also discusses the mechanisms by which EVs contribute to these diseases and the potential therapeutic interventions.

Chapters three to five focus on the enzymes and proteins involved in the inorganic phosphate and calcium turnover within mineralizing EVs. These chapters provide detailed insights into the biochemical machinery that drives the mineralization process and the dynamic properties of the vesicles' peripheral proteins. The role of inorganic phosphate and calcium ions in the biogenesis and function of mineralizing EVs is explored, as well as the involvement of autophagy in this process.

Recent studies have revealed that the lumen of mineralizing EVs is partially filled with microRNAs (miRNAs). Chapter six considers research on the possible function of these vesicles as signalosomes, which play a crucial role in cell communication and tissue regulation.

The final five chapters of the book provide practical aspects of working with mineralizing EVs. They cover topics such as purification, proteomic and biophysical analyses, the use of biomimetic models, and mineralizing EVs in regenerative medicine. These chapters provide valuable guidance for researchers interested in studying these vesicles and their potential applications in clinical settings.

Overall, Mineralizing Vesicles: From Biochemical and Biophysical Properties to Their Roles in Physiology and Disease is a comprehensive and up-to-date resource for researchers and clinicians interested in understanding the properties and potential applications of mineralizing EVs. It will be invaluable to researchers in the field of extracellular vesicles and their potential clinical applications.

Dimension: 229 x 152 (mm)
ISBN-13: 9780323991582