Modern CNS Drug Discovery: Reinventing the Treatment of Psychiatric and Neurological Disorders

This textbook provides a comprehensive overview of the concepts, approaches, and technologies used in the discovery and development of new treatments for the central nervous system. It covers key steps from idea generation to drug registration and emphasizes translational research and clinical development. Written by experts from academia and industry, it offers valuable insights and best practices for early researchers in drug discovery.

Format: Hardback
Length: 283 pages
Publication date: 17 June 2021
Publisher: Springer Nature Switzerland AG

This comprehensive textbook offers a thorough exploration of the cutting-edge concepts, methodologies, and technologies employed in the discovery and development of novel treatments for the diverse range of disorders affecting the central nervous system. It serves as a valuable guide for readers, taking them through the essential steps from ideation to the registration of a new drug.

The book is organized into four sections, each providing a distinct perspective on central nervous system drug discovery. The first section provides a broad overview of current approaches in CNS drug discovery, encompassing target identification, novel treatment strategies, and early discovery processes. An illustrative example of a novel treatment paradigm, brain stimulation, is presented to demonstrate the practical application of these concepts.

The second section delves into the generation of ideas for identifying targets and developing innovative treatment strategies. It covers key functions in early discovery, such as target validation and drug screening, and showcases the use of cutting-edge technologies, such as high-throughput screening and molecular modeling, to accelerate the drug discovery process.

The third section focuses on translational CNS drug discovery, emphasizing strategies and technologies that bridge the gap between discovery and clinical development. It discusses brain imaging, electroencephalography (EEG), and cognitive testing approaches as tools for assessing the efficacy and safety of potential treatments. This section also highlights the importance of clinical trials and the regulatory considerations involved in drug registration.

The fourth section extensively explores the clinical phase of drug development, covering the fundamentals of early clinical testing for psychopharmacological drugs. It discusses study design, participant selection, and data analysis techniques, providing insights into the evaluation of drug efficacy and safety in human subjects.

The book is authored by experts from both academia and industry, ensuring a balanced and up-to-date perspective on drug discovery. It covers essential basics and best practices, as well as recent developments in the field. This comprehensive resource serves as an invaluable guide for early researchers seeking to pursue a career in drug discovery in academia or industry.

In conclusion, this textbook provides a comprehensive and authoritative overview of the current state-of-the-art in central nervous system drug discovery. It equips readers with the knowledge and tools necessary to navigate the complex landscape of drug development, from ideation to clinical implementation. With its in-depth insights and practical guidance, it is an essential resource for researchers, practitioners, and policymakers alike.

Weight: 712g
Dimension: 187 x 262 x 23 (mm)
ISBN-13: 9783030623500
Edition number: 1st ed. 2021