Shulph Ink
Modern Methods of Drug Design and Development
Modern Methods of Drug Design and Development
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Modern Methods of Drug Design and Development, a volume in the Methods in Enzymology series, highlights new advances in the field, including recombinant protein purification, steady-state kinetic analysis, NMR techniques, dynamic simulations, and sensitive high throughput methods to screen for P450 inhibition. Other chapters cover acetyltransferase Eis inhibitors, crystallographic fragment screening, chemical biology, enzymology, and drug discovery, PROTACs, and proximity-induced pharmacology.
Format: Hardback
Length: 598 pages
Publication date: 17 October 2023
Publisher: Elsevier Science Publishing Co Inc
Modern Methods of Drug Design and Development, a volume in the Methods in Enzymology series, showcases exciting advancements in this field. This new edition presents captivating chapters on diverse topics, such as Recombinant protein purification for structural and kinetic studies, Steady-state kinetic analysis of reversible enzyme inhibitors, Steady-State Enzyme Kinetics, Analysis of enzyme kinetic data using ICEKAT, NMR techniques in drug discovery, Dynamic simulations and pre-steady state kinetics to guide drug discovery, Design and assay of substrate-product analogues for racemases and epimerases, Sensitive high throughput methods to screen for P450 inhibition: A-MI complex forming drugs, and much more.
Other chapters delve into Sensitive high throughput methods to screen for P450 inhibition: B-Heme loss causing drugs, Discovery and development of inhibitors of acetyltransferase Eis to combat Mycobacterium tuberculosis, Crystallographic fragment screening in academic cancer drug discovery, Fast fragment- and compound-screening pipeline at the Swiss Light Source, Chemical biology, enzymology, and drug discovery, PROTACs, Proximity-Induced Pharmacology (PROTACs), and numerous other subjects.
This comprehensive resource offers valuable insights into the latest methodologies and strategies employed in drug design and development, providing researchers and practitioners with a valuable tool for advancing their understanding and expertise in this field.
Weight: 450g
Dimension: 229 x 151 (mm)
ISBN-13: 9780443158711
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