mRNA Vaccines

This book discusses the development of fully synthetic mRNA vaccines, their formulation, technological advancements, and applications in infectious diseases and other indications. The success of mRNA-based COVID-19 vaccines supports their use as an attractive alternative to conventional vaccine approaches. The book covers production, capabilities, clinical development, safety, regulatory issues, and potential challenges to the mRNA vaccination approach. mRNA vaccines offer high potency, generic manufacturing, and synthetic nature, with the potential to minimize the time between pathogen identification and vaccine release, impacting public health significantly.

Format: Hardback
Length: 205 pages
Publication date: 04 January 2023
Publisher: Springer International Publishing AG

This volume delves into the intricate realm of RNA biology, chemistry, stability, and encapsulated delivery systems, which have played pivotal roles in the development of fully synthetic mRNA vaccines. It explores the diverse applications of mRNA technology, focusing on infectious diseases but also touching on other indications such as immunotherapies and molecular therapies. The remarkable immune responses observed in animal models, coupled with encouraging data from early human clinical studies, and the remarkable success of two mRNA-based COVID-19 vaccines have solidified the use of mRNA-based vaccination as an attractive alternative to conventional vaccine approaches. Consequently, this book provides a comprehensive review of the technology's development progress, particularly in terms of production capabilities, clinical development, and safety considerations. Additionally, it addresses regulatory issues and potential challenges to the mRNA vaccination approach, rounding off the comprehensive coverage of this transformative technology.

The future of mRNA vaccines is highly promising due to their exceptional potency, potential for generic, low-cost manufacturing processes, and entirely synthetic nature. Importantly, mRNA vaccines have the potential to significantly shorten the time between pathogen identification and vaccine release, thereby having a profound impact on public health.

As the mRNA-based vaccination technology continues to evolve at a rapid pace, this book serves as an end-to-end review series, encompassing all aspects from basic RNA biology and preclinical studies to manufacturing strategies, clinical development, and regulatory approval. It caters to established RNA researchers and developers, providing them with up-to-date advancements in the field and offering a concise yet comprehensive overview of this transformative technology, its applications, and its immense future potential.

Weight: 500g
Dimension: 235 x 155 (mm)
ISBN-13: 9783031180699
Edition number: 1st ed. 2022