Nanoparticle-Mediated Immunotherapy

Nanotechnology and immunotherapy have combined to create a promising treatment modality for cancer. Nanoparticles, such as polymeric and liposomal nanosystems, carbon nanotubes, and gold nanoparticles, have improved delivery and efficacy of immunotherapeutic agents, such as vaccines or adjuvants. Plasmonic nanoparticles have enhanced optical and electromagnetic properties and can convert photon energy into heat for selective photothermal therapy. Nanoparticle sizes can be controlled to accumulate preferentially in tumors, and various nanosystems, such as gold nanoparticles, have been shown to stimulate the immune system. Nanoparticle-mediated immunotherapy could lead to long-term immunological memory and provide protection against tumor recurrence.

Format: Paperback / softback
Length: 263 pages
Publication date: 13 October 2022
Publisher: Springer Nature Switzerland AG

This comprehensive book serves as an invaluable resource for a wide range of individuals engaged in research, teaching, learning, and practical applications of nanotechnology in immunotherapy. The integration of nanotechnology and immunotherapy has emerged as a highly promising therapeutic approach, particularly in the field of cancer treatment. The utilization of nanoparticles in immunotherapy has garnered significant attention due to their unique efficacy and specificity in targeting cancer cells. A diverse array of nanoparticles, including polymeric and liposomal nanosystems, carbon nanotubes, and gold nanoparticles, have provided essential platforms for immunotherapeutic strategies. These nanoparticles have demonstrated the ability to enhance the delivery and effectiveness of immunotherapeutic agents such as vaccines and adjuvants.

Nanoparticle-mediated thermal therapy has proven to be a highly effective method for precise tumor cell ablation, radio-sensitization of hypoxic regions, enhancement of drug delivery, activation of thermosensitive agents, and stimulation of the immune system. Plasmonic nanoparticles, a special class of metallic nanoparticles, have gained significant interest due to their enhanced optical and electromagnetic properties and their remarkable ability to convert photon energy into heat for selective photothermal therapy at the nanoscale level. Furthermore, nanoparticle sizes can be precisely controlled to accumulate preferentially in tumors, benefiting from the enhanced permeability and retention effect of tumor vasculature. Various nanosystems, such as gold nanoparticles, have also been shown to stimulate the immune system, further augmenting the therapeutic benefits of immunotherapies.

The combination of targeted nanoparticle-mediated photothermal therapies with immunotherapies, particularly when hyperthermia is combined with precise thermal targeting around immune-checkpoint inhibitors in the tumor bed, holds immense potential for synergistic effects. This approach can enhance the immune response, improve treatment outcomes, and overcome the challenges associated with cancer therapy. By leveraging the unique properties of nanoparticles and thermal therapies, researchers and healthcare professionals can develop innovative and personalized approaches to cancer treatment, leading to improved patient care and better outcomes.

Weight: 427g
Dimension: 235 x 155 (mm)
ISBN-13: 9783030783402
Edition number: 1st ed. 2021