Natural and Artificial Metalloenzymes: Faraday Discussion 234

Bioinorganic chemistry is a multidisciplinary field that explores the function of metalloenzymes and small molecules, activation, synthetic analogs, artificial enzymes, and therapeutic use of metal-ligand complexes. This volume brings together experts from various fields to discuss current insights and methodologies.

Format: Hardback
Length: 406 pages
Publication date: 10 June 2022
Publisher: Royal Society of Chemistry

The captivating realm of bioinorganic chemistry emerges as one of the most intellectually stimulating and experimentally challenging frontiers in contemporary chemical science. The intricate problems within this interdisciplinary field intertwine the realms of chemistry, biology, and medicine, offering a rich tapestry of fascination. This comprehensive volume unites esteemed experts in bioinorganic chemistry, seamlessly connecting them with spectroscopic and computational/theoretical physical chemists, fostering a collaborative exploration of cutting-edge mechanistic insights into the enigmatic functioning of numerous metalloenzymes. Moreover, it delves into the realm of small molecule activation, employing synthetic analog approaches to metalloproteins/enzymes, the creation of artificial enzymes, the therapeutic potential of metal-ligand complexes, and the methodologies employed in this dynamic field of research.

Within the pages of this volume, a diverse range of topics are meticulously addressed. These include:

Small molecule activation and synthetic analogues: This section delves into innovative strategies for activating small molecules, employing synthetic analogues to mimic the catalytic activities of metalloenzymes. It explores the development of novel catalysts, the design of efficient synthetic routes, and the exploration of the underlying mechanisms that govern these reactions.

Techniques for studying the kinetics and thermodynamics of metal-ligand exchange reactions: This section highlights the development of experimental and theoretical methodologies to study the kinetics and thermodynamics of metal-ligand exchange reactions. It encompasses techniques such as stopped-flow kinetic analysis, thermodynamic measurements, and computational simulations, enabling researchers to gain a deeper understanding of the complex dynamics involved in these reactions.

Electron transfer, spectroscopy, and theory: This section explores the intricate mechanisms of electron transfer within metalloenzymes and related systems. It discusses the use of spectroscopic techniques, such as UV-Vis, infrared, and electron paramagnetic resonance (EPR) spectroscopy, to unravel the electronic structure and dynamics of these complexes. It also delves into theoretical approaches, such as density functional theory (DFT), to simulate and predict the behavior of these systems.

Natural and artificial enzymes and medicinal aspects: This section explores the role of enzymes in biological processes and their potential applications in medicine. It discusses the discovery and characterization of natural enzymes, as well as the development of artificial enzymes and their applications in drug discovery, biosensing, and other fields. It also explores the therapeutic use of metal-ligand complexes in the treatment of diseases, such as cancer and infectious diseases.

In summary, this volume serves as a valuable resource for researchers and scholars in bioinorganic chemistry, providing a comprehensive and up-to-date overview of the field. It showcases the interdisciplinary nature of bioinorganic research, bridging the gap between chemistry, biology, and medicine. By bringing together experts from diverse backgrounds, the volume fosters a rich exchange of ideas, enabling the development of new insights and breakthroughs that will shape the future of this dynamic field.

Weight: 726g
Dimension: 234 x 156 (mm)
ISBN-13: 9781839165665