Navigating Non-coding RNA: From Biogenesis to Therapeutic Application

Navigating Non-coding RNA: From Biogenesis to Therapeutic Application is a comprehensive guide to the field of non-coding RNA, covering its history, types, functions, and regulation. It also explores epitranscriptomic modifications and their role in diseases and therapeutic applications.

Format: Paperback / softback
Length: 448 pages
Publication date: 30 June 2023
Publisher: Elsevier Science & Technology

Non-coding RNA (ncRNA) is a fascinating field that has been the subject of extensive research in recent years. Navigating Non-coding RNA: From Biogenesis to Therapeutic Application provides a comprehensive overview of this rapidly evolving area. The book spans multiple chapters, each dedicated to exploring different aspects of ncRNA.

The history of ncRNA discoveries is traced back to the early 1960s when scientists first identified small RNAs (sRNAs) in bacteria. Since then, the field has expanded significantly, with the identification of various types of ncRNAs, including ribosomal RNA (rRNA), transfer RNA (tRNA), small nuclear RNA (snRNA), and telomerase RNA.

Housekeeping ncRNAs, such as rRNA and tRNA, play crucial roles in the synthesis of proteins and the regulation of gene expression. These RNAs are involved in various processes, such as splicing, translation, and ribosome assembly. Transfer RNA, in particular, is responsible for carrying amino acids to the ribosome during protein synthesis.

Regulatory ncRNAs, on the other hand, are involved in the regulation of gene expression at the post-transcriptional level. These include microRNAs (miRNAs), small interfering RNAs (siRNAs), long non-coding RNAs (lncRNAs), and Y RNAs. MiRNAs are short RNAs that bind to specific messenger RNA (mRNA) sequences and inhibit their translation, while siRNAs are longer RNAs that also bind to mRNA and induce gene silencing. LncRNAs, on the other hand, are non-coding RNAs that are longer than 200 nucleotides and play important roles in gene regulation and epigenetic regulation.

The book also delves into the biogenesis, structure, function, and regulation of ncRNAs. It explores the mechanisms by which ncRNAs are produced from DNA and the roles that various proteins and enzymes play in their biogenesis. The structure of ncRNAs is also discussed, including their secondary and tertiary structures, which are crucial for their function.

In addition to traditional and cutting-edge methods for the identification, functional characterization, and structural characterization of ncRNAs, the book also focuses on the different types of epitranscriptomic modifications that occur on ncRNAs. These modifications include methylation, acetylation, and phosphorylation, which play important roles in regulating ncRNA structure, stability, and intermolecular interactions.

The role of ncRNAs in a range of diseases is also explored. ncRNAs have been implicated in various human diseases, including cancer, cardiovascular disease, and neurological disorders. Understanding the role of ncRNAs in these diseases is crucial for developing new therapeutic strategies.

The book also highlights the potential therapeutic applications of ncRNAs. ncRNAs can be used as biomarkers for disease diagnosis, as they can be detected in body fluids such as blood and urine. They can also be used as therapeutic agents, either as standalone treatments or in combination with other therapies. For example, miRNAs have been used in the treatment of cancer, while lncRNAs have been used to treat cardiovascular disease.

In conclusion, Navigating Non-coding RNA: From Biogenesis to Therapeutic Application is an essential resource for researchers, students, and clinicians interested in ncRNA. The book provides a comprehensive overview of the field, covering the history of discoveries, specific types of ncRNAs, housekeeping ncRNAs, regulatory ncRNAs, biogenesis, structure, function, and regulation. It also explores the different types of epitranscriptomic modifications and their involvement in regulating ncRNA structure, stability, and intermolecular interactions. The book also highlights the potential therapeutic applications of ncRNAs and their potential to revolutionize the field of medicine.

Weight: 726g
Dimension: 153 x 229 x 24 (mm)
ISBN-13: 9780323904063