Network Pharmacology

Network Pharmacology is an emerging field that combines system biology, bioinformatics, network science, and other related disciplines to analyze the molecular associations between drugs and their treatment objects, revealing the systematic pharmacological mechanisms of drugs and guiding the research and development of new drugs and clinical diagnosis and treatment. It was proposed to construct a biological network to decipher complex diseases and has become the core theory of network pharmacology. This book mainly includes four parts: the concept and theory of network pharmacology, common analysis methods, databases and software, typical cases of traditional Chinese medicine modernization and modern drug research, and network pharmacology practice processes based on drugs and diseases.

Format: Hardback
Length: 468 pages
Publication date: 30 September 2021
Publisher: Springer Verlag, Singapore

This captivating book delves into the emerging realm of "network pharmacology" as a groundbreaking field of systematic drug research in the era of artificial intelligence and big data. Network Pharmacology emerges as an innovative subject of fusion, drawing upon system biology, bioinformatics, network science, and other related disciplines. It places a strong emphasis on understanding drugs and their therapeutic effects from a holistic system-level and biological network perspective. By meticulously analyzing the intricate laws governing the molecular associations between drugs and their treatment targets, the book unveils the underlying systematic pharmacological mechanisms at play. This insightful exploration guides the research and development of new drugs, as well as the clinical diagnosis and treatment of various diseases.

Since its proposal, network pharmacology has garnered significant attention from researchers, experiencing rapid development and widespread application. In order to unravel the biological foundations of diagnosis and treatment in traditional Chinese medicine and modern medicine, we introduced a novel concept of network target for the first time, which has since become the cornerstone of network pharmacology. The core principle of a network target revolves around constructing a biological network that can decipher complex diseases. This network serves as the therapeutic target, upon which multicomponent remedies are applied.

This comprehensive book is divided into four insightful parts:
1. The Concept and Theory of Network Pharmacology: This section provides a foundational understanding of network pharmacology, exploring its theoretical framework, principles, and methodologies. It delves into the concepts of drug-target interactions, network analysis, and drug repositioning, highlighting the importance of integrating multiple disciplines for comprehensive drug discovery.
2. Common Analysis Methods, Databases, and Software in Network Pharmacological Research: This part offers a comprehensive overview of the analytical tools and resources employed in network pharmacological research. It discusses popular databases, software platforms, and computational methods used to identify drug-target interactions, construct biological networks, and analyze data. It also provides insights into data mining techniques and machine learning algorithms that aid in the interpretation of complex network data.
3. Typical Cases of Traditional Chinese Medicine Modernization and Modern Drug Research Based on Network Pharmacology: This section showcases real-world examples of traditional Chinese medicine modernization and modern drug research utilizing network pharmacology. It highlights successful cases where traditional Chinese medicine compounds have been repurposed as novel drugs or where network analysis has aided in the discovery of new drug targets. It also discusses the challenges and opportunities associated with integrating traditional knowledge with modern drug discovery approaches.
4. Network Pharmacology Practice Process Based on Drugs and Diseases: This part provides a practical guide for applying network pharmacology in drug discovery and clinical practice. It discusses the steps.

In conclusion, this book serves as a valuable resource for researchers, practitioners, and students interested in exploring the frontier of network pharmacology. It provides a comprehensive and up-to-date overview of the field, covering its theoretical foundations, analytical methods, practical applications, and future prospects. By integrating multiple disciplines and leveraging advanced technologies, network pharmacology holds immense potential to revolutionize drug discovery, personalized medicine, and disease treatment. As we continue to unravel the complex biological networks underlying drug response and disease progression, this book will undoubtedly remain a cornerstone in advancing our understanding of therapeutics and improving patient outcomes.

Weight: 893g
Dimension: 235 x 155 (mm)
ISBN-13: 9789811607523
Edition number: 1st ed. 2021