Neuroglia: Function and Pathology

Diverse specialized neuroglial cells ensure the development, preservation, and health of the central nervous system, peripheral nervous system, enteric nervous system, and special senses. In the central nervous system, astrocytes, oligodendrocytes, and microglia safeguard nerve cell function and integrity. In the peripheral nervous system, Schwann cells and satellite glial cells ensure correct communication. In the enteric nervous system, specialized enteric glial cells maintain gastrointestinal function. In pathology, neuroglia protect the nervous system and are responsible for posttraumatic restructuring. Neuroglia: Function and Pathology provides a comprehensive account of glial cell physiology and pathophysiology in the central and peripheral nervous systems, emphasizing their roles in neurological disorders and potential as therapeutic targets.

Format: Hardback
Length: 730 pages
Publication date: 17 May 2023
Publisher: Elsevier Science Publishing Co Inc

The intricate network of specialized neuroglial cells plays a vital role in the development, maintenance, and overall health of the central nervous system, peripheral nervous system, enteric nervous system, and special senses. Within the central nervous system, astrocytes, oligodendrocytes, and microglia assume critical guardianship over the functioning and integrity of nerve cells. These cells, collectively known as glia, exert control over all human behaviors and encompass the cerebral cortex, the seat of humanity's consciousness. In the peripheral nervous system, Schwann cells take center stage, alongside satellite glial cells of sensory and autonomic ganglia, ensuring seamless communication between the organs, tissues, brain, and spinal cord. Meanwhile, in the enteric nervous system, specialized enteric glial cells maintain the intricate balance of gastrointestinal function. Additionally, there exist distinct glial cells of the special senses that orchestrate how the body perceives and responds to its environment.

In the realm of pathology, neuroglia emerge as formidable protectors of the diverse cellular components of the nervous system. They are responsible for implementing a proactive program of posttraumatic restructuring, aimed at restoring vital functions and promoting recovery. Neuroglia: Function and Pathology offers a groundbreaking and comprehensive exploration of the physiology and pathophysiology of glial cells in the central and peripheral nervous systems. The first part of the book delves into the intricate details of glial cell formation and function, spanning their evolutionary origins in invertebrates to their remarkable complexity in humans. It encompasses a comprehensive description of the developmental origins of various glial cell types, their diverse morphologies, molecular biology, and cellular physiology.

The second part of the book is dedicated to a thorough examination of glial cell pathophysiology. It begins with definitive explanations of fundamental concepts, such as glial cell activation, neuroinflammation, and neurodegeneration. The book then proceeds to explore the diverse mechanisms underlying glial cell-mediated disorders, including ischemic stroke, spinal cord injury, and neurodegenerative diseases. By providing a comprehensive understanding of glial cell function and pathology, Neuroglia: Function and Pathology serves as a valuable resource for researchers, clinicians, and students in the fields of neuroscience, neurology, and pathology. It sheds light on the crucial role of glia in maintaining nervous system health and highlights the potential for therapeutic interventions in glial-related disorders.

Weight: 2120g
Dimension: 220 x 287 x 41 (mm)
ISBN-13: 9780128215654