Neurotoxicity of Halogenated Organic Compounds

Halogenated Organic Compounds are a class of chemicals that are known to be neurotoxic. This volume covers three groups of halogenated organic compounds (chlorinated, brominated, and fluorinated compounds) that are legacy and emerging contaminants, providing background information, characteristics, physicochemical properties, environmental contamination, and human exposure.

Format: Hardback
Length: 300 pages
Publication date: 01 October 2023
Publisher: Elsevier Science Publishing Co Inc

Neurotoxicity of Halogenated Organic Compounds, Volume 10 delves into three groups of halogenated organic compounds: chlorinated, brominated, and fluorinated compounds. These compounds, both legacy and emerging contaminants, are explored in terms of their background information, characteristics, physicochemical properties, environmental contamination, and human exposure. Within this comprehensive volume, specific chapters delve into various aspects of halogenated organic compounds.

"Perspective on Halogenated Organic Compounds" provides an overview of the significance and challenges associated with these compounds. It highlights their historical usage, widespread distribution, and potential health risks.

"The Neurotoxicity of Polychlorinated Biphenyls (PCBs)" delves into the neurotoxic effects of polychlorinated biphenyls (PCBs), a group of highly toxic chemicals that were extensively used in electrical equipment and other products. The chapter explores the mechanisms of PCB neurotoxicity, including the involvement of the aryl hydrocarbon receptor (AHR) and thyroid hormone receptor (THR) pathways, as well as the reality of the receptor yolk protein (RYR) hypothesis.

"Neuroendocrine Effects of Polychlorinated Biphenyls (PCBs)" examines the endocrine-disrupting properties of PCBs and their impact on human health. It discusses the mechanisms by which PCBs disrupt hormonal signaling pathways, leading to various adverse effects on the nervous system and reproductive health.

"Mechanisms of PCB Neurotoxicity: AHR and THR Dogma meet RYR Reality" explores the complex mechanisms of PCB neurotoxicity, examining the interplay between different receptor pathways and their potential roles in mediating PCB effects. The chapter discusses the challenges in understanding the full spectrum of PCB neurotoxicity and highlights the need for further research.

"Microbiome and the Neurotoxicity of Brominated Flame Retardants (BFRs)" explores the relationship between the microbiome and the neurotoxicity of brominated flame retardants (BFRs). BFRs are commonly used in various products to prevent fire, but their exposure has been linked to neurological disorders and other health concerns. The chapter discusses the potential mechanisms by which BFRs disrupt the microbiome and impact human health.

"Neurochemical Effects of Halogenated Organic Compounds: Possible Mode(s) of Action and Structure-Activity Relationships" examines the neurochemical effects of halogenated organic compounds, including their potential modes of action and structure-activity relationships. The chapter discusses the role of these compounds in neurotoxicity and explores the potential for developing safer alternatives.

"The Neurotoxic Effects of Perfluoroalkyl Substances (PFAS) in Animal Models and Human Cohorts" explores the neurotoxic effects of perfluoroalkyl substances (PFAS), a group of chemicals used in a wide range of products, including firefighting foam, nonstick cookware, and waterproof clothing. The chapter discusses the animal models used to study PFAS neurotoxicity and the human cohorts that have been exposed to these compounds.

"Neurochemical Mechanisms of Perfluoroalkyl Substances (PFAS) Neurotoxic Action" delves into the mechanisms by which PFAS exert their neurotoxic effects. The chapter discusses the potential mechanisms of neuroinflammation, oxidative stress, and neurotoxicity and highlights the need for further research to understand these processes.

"Future Directions and Regulatory Aspects of Halogenated Organic Compounds" provides insights into the future directions and regulatory aspects of halogenated organic compounds. The chapter discusses the ongoing efforts to address the environmental and health risks associated with these compounds and the need for effective regulations and policies to protect human health and the environment.

In conclusion, Neurotoxicity of Halogenated Organic Compounds, Volume 10 is a comprehensive and authoritative resource that provides valuable insights into the neurotoxicity of halogenated organic compounds. The book covers a wide range of topics, including the background information, characteristics, physicochemical properties, environmental contamination, and human exposure of these compounds. Each chapter is written by experts in the field, and the content is updated to reflect the latest research and developments. This book is essential for researchers, policymakers, and healthcare professionals interested in understanding the neurotoxicity of halogenated organic compounds and their potential impacts on human health.

Weight: 450g
Dimension: 229 x 152 (mm)
ISBN-13: 9780443133404