New Strategies Targeting Cancer Metabolism: Anticancer Drugs, Synthetic Analogues and Antitumor Agents

Anticancer drugs, synthetic analogues, and antitumor agents are important in medical research, treating critical diseases like cancer, malignancies, autoimmune diseases, and non-malignant diseases. This book explores novel synthetic strategies for anticancer alkylating agents, natural products, and insights into novel compounds for further anticancer drug development and discovery. It is a valuable resource for medical chemists, pharmacologists, and biochemists.

Format: Paperback / softback
Length: 628 pages
Publication date: 01 May 2022
Publisher: Elsevier Science Publishing Co Inc

New Strategies Targeting Cancer Metabolism: Anticancer Drugs, Synthetic Analogues, and Antitumor Agents presents up-to-date synthetic strategies for three categories of antimetabolites: antifolates, purines, and pyrimidines, the main classes of antimetabolites integrated into various pharmaceutical agents. Many of these antimetabolites are considered potent chemotherapeutic agents with great potential impact on medical research. These main classes of antimetabolites are used in the treatment of critical diseases, including cancer, malignancies, autoimmune diseases, and many other non-malignant diseases. Antineoplastic drugs such as alkylating agents, which have significant effects, are described. Novel synthetic strategies for many anticancer alkylating agents, including nitrogen mustards, chlorambucil, melphalan, ifosamide, oxaliplatin, and temozolomide, are explored. Natural products have offered some of the most significant drugs for treating cancer, as many drugs currently in clinical use are derived from natural products, such as camptothecins, vinca alkaloids, and derivatives of podophyllotoxin. They provide a contribution that is essential for modern drug discovery and development. In this book, insights into a broad array of novel compounds are reviewed, well-recognized synthetic approaches are emphasized for further anticancer drug development and discovery, and the biological evaluation of novel synthesized compounds are included. This comprehensive reference is a valuable resource for medical chemists working in drug discovery and development, as well as pharmacologists and biochemists working in related fields.

Dimension: 229 x 152 (mm)
ISBN-13: 9780128217832