Next-Generation Nanobiosensor Devices for Point-Of-Care Diagnostics

This book explores the potential of next-generation point-of-care diagnosis in healthcare, focusing on printed chip-based assays and sensory systems based on nanomaterials. It also examines electrochemical concepts for cancer theranostics and wearable hemodynamic sensors. It highlights the challenges and opportunities in point-of-care testing.

Format: Hardback
Length: 249 pages
Publication date: 03 December 2022
Publisher: Springer Verlag, Singapore

This comprehensive book delves into the promising realm of next-generation point-of-care diagnosis in healthcare, exploring the potential of printed chip-based assays (Lab-on-a-Chip,Lab-on-a-PCB) for rapid and cost-effective biomarker detection. It also presents the development of sensory systems based on nanomaterials, examining various biosensors for medical diagnosis through surface modification strategies of transducers. Furthermore, it delves into electrochemical concepts utilizing different nanobiomaterials and nanocomposites for cancer theranostics, highlighting the recent advancements in wearable, cost-effective hemodynamic sensors for early disease detection. Additionally, the book explores the combination of redox cycling and electrochemical detection to create ultrasensitive and reproducible biosensors for point-of-care testing. Finally, it summarizes the significant challenges in point-of-care diagnostics and outlines the exciting future opportunities in healthcare.

Introduction:
The field of point-of-care diagnostics holds immense potential for improving healthcare outcomes by enabling timely and accurate disease detection at the point of care. With the advent of next-generation technologies, there is a growing interest in developing rapid, inexpensive, and portable diagnostic tools that can be used in resource-limited settings. This book aims to review the latest developments in point-of-care diagnosis and explore the potential of printed chip-based assays (Lab-on-a-Chip,Lab-on-a-PCB) for rapid, inexpensive biomarker detection.

Printed Chip-Based Assays:
Printed chip-based assays are a promising technology for point-of-care diagnosis due to their ability to combine miniaturization, multiplexing, and automation. These assays utilize microfluidic channels and microelectronic components to perform various analytical operations, such as sample preparation, detection, and quantification. One of the key advantages of printed chip-based assays is their ability to detect multiple biomarkers simultaneously, which can greatly enhance the diagnostic accuracy and sensitivity.

Lab-on-a-Chip:
Lab-on-a-Chip, also known as Lab-on-a-PCB, is a printed chip-based assay that combines microfluidic channels, microelectronic components, and microsensors. It is designed to perform various analytical operations, including sample preparation, detection, and quantification, on a single chip. Lab-on-a-Chip assays are highly portable, inexpensive, and easy to use, making them ideal for point-of-care testing.

Rapid, Inexpensive Biomarker Detection:
Printed chip-based assays have the potential to revolutionize the field of point-of-care diagnosis by enabling rapid and inexpensive biomarker detection. These assays can be used to detect a wide range of diseases, including infectious diseases, cancer, and cardiovascular diseases. By combining microfluidic technology with microelectronic components, printed chip-based assays can achieve high sensitivity and specificity, making them suitable for use in resource-limited settings.

Sensory Systems Based on Nanomaterials:
Sensory systems based on nanomaterials have the potential to enhance the sensitivity and specificity of biosensors for medical diagnosis. Nanomaterials, such as carbon nanotubes, gold nanoparticles, and silver nanoparticles, have unique properties that can be exploited to improve the performance of biosensors. For example, carbon nanotubes can be used to enhance the electrochemical properties of biosensors, while gold nanoparticles can be used to enhance the optical properties of biosensors.

Biosensors for Medical Diagnosis:
Biosensors for medical diagnosis play a crucial role in point-of-care testing. These sensors are designed to detect specific biomarkers in biological samples, such as blood, urine, or saliva. Biosensors can be used to detect a wide range of diseases, including infectious diseases, cancer, and cardiovascular diseases. By using surface modification strategies of transducers, biosensors can be tailored to detect specific biomarkers with high sensitivity and specificity.

Electrochemical Concepts:
Electrochemical concepts based on different nanobiomaterials and nanocomposites have the potential to develop ultrasensitive and reproducible biosensors for point-of-care testing. These biosensors can be used to detect a wide range of diseases, including cancer, infectious diseases, and cardiovascular diseases. By using electrochemical techniques, such as voltammetry, amperometry, and electrochemical impedance spectroscopy, biosensors can achieve high sensitivity and specificity, making them suitable for use in resource-limited settings.

Wearable, Cost-Effective Hemodynamic Sensors:
Wearable, cost-effective hemodynamic sensors have the potential to detect diseases at an early stage. These sensors are designed to monitor the physiological parameters of the body, such as blood pressure, heart rate, and oxygen saturation. By using these sensors, healthcare professionals can monitor the health of patients in real-time and detect early signs of disease.

Combination of Redox Cycling and Electrochemical Detection:
Combination of redox cycling and electrochemical detection has the potential to develop ultrasensitive and reproducible biosensors for point-of-care testing. These biosensors can be used to detect a wide range of diseases, including cancer, infectious diseases, and cardiovascular diseases. By combining redox cycling and electrochemical detection, biosensors can achieve high sensitivity and specificity, making them suitable for use in resource-limited settings.

Challenges in Point-of-Care Diagnostics:
Despite the promising potential of printed chip-based assays, Lab-on-a-Chip, and wearable, cost-effective hemodynamic sensors, there are several challenges that need to be addressed. These challenges include the need for improved sensitivity and specificity, the need for miniaturization and portability, and the need for low-cost manufacturing.

Future Opportunities in Healthcare:
Despite the challenges, there are several exciting opportunities for point-of-care diagnostics in healthcare. These opportunities include the development of new technologies, such as artificial intelligence and machine learning, the integration of wearable devices, and the development of new diagnostic tools for emerging diseases.

Conclusion:
In conclusion, this book reviews the potential of next-generation point-of-care diagnosis in healthcare, exploring the potential of printed chip-based assays for rapid, inexpensive biomarker detection. It also presents the development of sensory systems based on nanomaterials, examining various biosensors for medical diagnosis through surface modification strategies of transducers. Furthermore, it delves into electrochemical concepts utilizing different nanobiomaterials and nanocomposites for cancer theranostics, highlighting the recent advancements in wearable, cost-effective hemodynamic sensors for early disease detection. Additionally, the book explores the combination of redox cycling and electrochemical detection to create ultrasensitive and reproducible biosensors for point-of-care testing. Finally, it summarizes the significant challenges in point-of-care diagnostics and outlines the exciting future opportunities in healthcare.

Weight: 559g
Dimension: 235 x 155 (mm)
ISBN-13: 9789811971297
Edition number: 1st ed. 2023