Nmr With Biological Macromolecules In Solution: A Selection Of Papers Published From 1996 To 2020 By Kurt Wuthrich

The book provides insights into the research of the Kurt Wüthrich laboratories from 1996-2020, highlighting advancements in nuclear magnetic resonance (NMR) spectroscopy in solution and its applications in structural biology. It covers studies of prion proteins, the SARS-Corona virus proteome, G protein-coupled receptor signaling, and pheromone signal transfer, placing key publications in perspective.

Format: Hardback
Length: 264 pages
Publication date: 03 November 2021
Publisher: World Scientific Publishing Co Pte Ltd

The book delves into a comprehensive exploration of the groundbreaking research conducted by the Kurt Wüthrich laboratories from 1996 to 2020. During this transformative period, nuclear magnetic resonance (NMR) spectroscopy in solution experienced remarkable advancements, evolving into a widely adopted standard technique in structural biology. The introduction of TROSY (transverse relaxation-optimized spectroscopy) marked a significant milestone, expanding the range of accessible molecular sizes by approximately thirtyfold. This technological breakthrough paved the way for efficient protein structure determination, aligning with the demands of the structural genomics initiative.

The applications of NMR spectroscopy in fundamental biology and biomedicine are diverse and far-reaching. These include in-depth studies of prion proteins and prion diseases (transmissible spongiform encephalopathies, or TSEs), the comprehensive analysis of the SARS-Corona virus proteome, the exploration of trans-membrane signaling by G protein-coupled receptors (GPCRs), and the investigation of signal transfer mechanisms through pheromones.

To provide a deeper understanding of the contributions made by the Kurt Wüthrich laboratories, this book places key publications from these research endeavors in context. It sheds light on novel aspects of NMR spectroscopy in structural biology, highlighting the methodologies developed and the diverse applications in biological research. These applications encompass areas such as prion proteins and their involvement in TSEs, the structural characterization of the SARS-Corona virus proteome, metabolic-flux profiling in bacterial cultures, and the study of signal transfers by pheromones.

The insights gained from this book not only expand our knowledge of structural biology but also have significant implications for various fields of biological research. By unraveling the complexities of molecular structures and interactions, NMR spectroscopy continues to be a powerful tool for advancing our understanding of life's fundamental processes. The work conducted by the Kurt Wüthrich laboratories serves as a testament to the enduring impact of scientific discovery and the power of interdisciplinary collaboration.

ISBN-13: 9789811235788