Nonhuman Primate Models in Preclinical Research: Basics and Regulatory Principles -- Volume 1

Non-human primates (NHP) are used in biomedical and behavioral research due to their close genetic and biological similarities with humans. However, their highly developed cognitive abilities and social skills make the use of these animals in research controversial. This book covers a wide range of NHP models in preclinical research and welfare issues, including refinement of the use of NHP, ethics and regulations, biological basis differences, MHC immunology, stem cell biology, neuro and gliogenesis, autoimmune disease, organ transplantation, infectious disease research, viral diseases, Parkinson's disease, neurodegenerative disorders, cardio-cerebrovascular disease research, islet transplantation, ophthalmic diseases research, transgenic engineering, cancer models, respiratory disease research, clinical and non-clinical pharmacology, lung transplantation, and aging research. The editors have invited experts from the United States, Canada, and Europe to contribute 23 chapters in their respective fields.

Format: Hardback
Length: 272 pages
Publication date: 01 September 2021
Publisher: Nova Science Publishers Inc

Non-human primates (NHPs) are a valuable resource in biomedical and behavioral research due to their phylogenetic relationship and close genetic and biological similarities with humans. However, their highly developed cognitive abilities and social skills have led to debates over their use in biomedical research. While NHPs are still essential in specific research areas, their use must be conducted under strict conditions that prioritize animal welfare. These conditions include providing appropriate housing, using non-invasive methods, and adhering to the 3Rs policy, which stands for reduction, refinement, and replacement. Despite the existence of nationally and internationally accepted guidelines on animal laboratory practice, their universal recognition is unfortunately lacking.

This book aims to provide a comprehensive overview of NHP models in preclinical research and welfare issues. It will cover various topics, including:

Refinement of the use of NHPs in biomedical research: This chapter will discuss strategies to improve the ethical and scientific use of NHPs in research. It will explore issues such as reducing the number of animals used, refining experimental procedures, and enhancing the welfare of animals during research.

NHP ethics and regulations in Europe: This chapter will provide an overview of the ethical and regulatory framework for using NHPs in research in Europe. It will discuss the legal requirements, ethical considerations, and guidelines that govern the use of NHPs in different European countries.

Biological basis differences in the human and NHP: This chapter will explore the biological differences between humans and NHPs, including their genetics, physiology, and behavior. It will discuss how these differences can impact the design and interpretation of research studies using NHPs.

The major histocompatibility complex (MHC) immunology in NHP: This chapter will discuss the MHC system, which plays a crucial role in immune response, and its relevance in NHP research. It will explore the MHC genetics, immunology, and its application in studying immune responses and diseases.

Stem cell biology in NHP: This chapter will discuss the use of stem cells in NHP research, including their isolation, differentiation, and application in studying diseases and developing therapies. It will also explore the ethical and regulatory considerations associated with stem cell research in NHPs.

Neuro and gliogenesis in an NHP ischemia stroke model: This chapter will discuss the use of NHP models to study neurodegenerative disorders, such as ischemia stroke. It will explore the cellular and molecular mechanisms involved in stroke and how NHP models can be used to develop novel therapies and diagnostic tools.

NHP models in autoimmune disease, organ transplantation, and infectious disease research: This chapter will discuss the use of NHP models in studying autoimmune diseases, organ transplantation, and infectious diseases. It will explore the immune responses, pathological processes, and drug responses in these diseases and how NHP models can be used to develop new treatments and vaccines.

Viral diseases in NHP: This chapter will discuss the use of NHP models to study viral diseases, including HIV/AIDS, Ebola, and COVID-19. It will explore the viral replication, immune responses, and pathological processes in these diseases and how NHP models can be used to develop novel therapies and vaccines.

NHP models in Parkinson's disease, neurodegenerative disorders research, and cardio-cerebrovascular disease research: This chapter will discuss the use of NHP models in studying Parkinson's disease, neurodegenerative disorders, and cardio-cerebrovascular diseases. It will explore the cellular and molecular mechanisms involved in these diseases and how NHP models can be used to develop novel therapies and diagnostic tools.

Islet transplantation: This chapter will discuss the use of NHP models to study islet transplantation, a potential treatment for diabetes. It will explore the cellular and molecular mechanisms involved in islet transplantation and how NHP models can be used to develop novel therapies and improve patient outcomes.

Ophthalmic diseases research and neurophysiology in NHP: This chapter will discuss the use of NHP models in studying ophthalmic diseases, including glaucoma, cataracts, and retinal degeneration. It will explore the cellular and molecular mechanisms involved in these diseases and how NHP models can be used to develop novel therapies and diagnostic tools.

Transgenic engineering in NHP: This chapter will discuss the use of genetic engineering techniques in NHP research, including gene knockout, gene insertion, and gene modification. It will explore the ethical and regulatory considerations associated with transgenic engineering and how NHP models can be used to study genetic diseases and develop novel therapies.

NHP models of cancers: This chapter will discuss the use of NHP models in studying cancer, including breast cancer, lung cancer, and prostate cancer. It will explore the cellular and molecular mechanisms involved in cancer development and how NHP models can be used to develop novel therapies and diagnostic tools.

NHP models in respiratory disease research: This chapter will discuss the use of NHP models in studying respiratory diseases, including asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis. It will explore the cellular and molecular mechanisms involved in these diseases and how NHP models can be used to develop novel therapies and diagnostic tools.

NHP models in clinical and non-clinical pharmacology: This chapter will discuss the use of NHP models in studying drug effects and drug safety. It will explore the pharmacokinetics, pharmacodynamics, and toxicology of drugs in NHPs and how NHP models can be used to develop novel drugs and improve drug safety.

NHP models in lung transplantation: This chapter will discuss the use of NHP models in studying lung transplantation, including the surgical procedures, immunological responses, and long-term outcomes. It will explore the ethical and regulatory considerations associated with lung transplantation and how NHP models can be used to improve patient outcomes.

Aging research in NHP: This chapter will discuss the use of NHP models in studying aging and age-related diseases, including Alzheimer's disease, Parkinson's disease, and cardiovascular disease. It will explore the cellular and molecular mechanisms involved in aging and how NHP models can be used to develop novel therapies and diagnostic tools.

In conclusion, non-human primates are a valuable resource in biomedical and behavioral research, but their use must be conducted under strict conditions that prioritize animal welfare. This book aims to provide a comprehensive overview of NHP models in preclinical research and welfare issues, covering various topics such as refinement of the use of NHPs, NHP ethics and regulations, biological basis differences, MHC immunology, stem cell biology, neuro and gliogenesis, autoimmune disease, organ transplantation, infectious disease research, viral diseases, Parkinson's disease, neurodegenerative disorders, cardio-cerebrovascular disease research, islet transplantation, ophthalmic diseases research, neurophysiology, transgenic engineering, NHP models of cancers, respiratory disease research, clinical and non-clinical pharmacology, lung transplantation, and aging research. By understanding the biological and ethical considerations associated with NHP research, we can advance our understanding of human health and disease and develop more effective treatments and therapies for patients.

Weight: 684g
ISBN-13: 9781536194401